Correlation between leptin and chronic periodontitis

One important function of leptin is the regulation of immune or inflammatory responses. Moreover, in a recent study no correlation between leptin and periodontal diseases was found. Therefore the aim of this study is to determine the correlation between leptin concentration and chronic periodontitis. In this analytical study, 20 healthy gingival tissue samples [control group] and 20 gingival tissues with advanced and moderate chronic periodontitis [case group] and 20 blood samples were taken from 20 patients. Patients were consisted of 55% females and 45% males with average age of 42.25 yrs. Tissue samples were cultured for 72 hours. In the case of blood samples, the serum was immediately collected. Then ELISA was used for detecting of leptin and IL-6 in supernatant fluids of explant cultures and leptin in serum samples. Statistical analysis was made by Paired T-test and Wilcoxon signed Ranks test. There was no leptin in gingival samples of both cases and control groups. The mean concentration of IL-6 in control and case groups was 81.08 +/- 36.72 and 90.35 +/- 29.71 pg/ml, respectively. Statistical analysis has shown no difference between case and control groups regarding IL-6 concentration. It is concluded that leptin does not have any role as an inflammatory protein in chronic periodontitis and regarding the absence of leptin in all of gingival samples, we could not consider gingiva as a possible source of leptin

[Fabrication of implant-supported ear prosthesis: report of a case]

Restoration of facial lesions has been always difficult for prosthodontists. Extraoral facial prosthesis are faced with apparent limitations such as base removable tissue, lack of large-sized prosthesis and intolerance by the patients. The use of implants may lead to a decrease in these limitations. The implant-induced retention can replace the largesized prosthesis in removable tissue bases and then, the attention may be focused on prosthesis esthetics only. The present study reports a case of implant - supported ear prosthesis with trauma history referring to Removable Prosthodontics Department of Dental School, Shaheed Beheshti University of Medical Sciences

Investigation of H pylori colonization in adenotonsillectomy specimens by means of rapid urease [CLO] test

This prospective clinical study was performed to investigate the colonization of H pylori in adenoid and tonsil tissues by using the Campylobacter-like organism [CLO] test. Included in the study were 56 patients aged 3 to 43 yrs who had undergone adenoidectomy, tonsillectomy or adenotonsillectomy procedures under general anesthesia. Two-mm diameter tissue pieces of adenoid and tonsil specimens were placed in urease solution. Color changes were noted after 30 min and 24 hrs. 27 [48.2%] of the patients were shown to be H pylori positive and 29 [51.8%] were negative, regardless of the type of specimen. There was a high rate of H pylori colonization in tonsil and adenoid tissues. The cause of recurrent H pylori infections of the gastric mucosa may be the result of colonization in the adenotonsillar tissues. Prevention of H pylori colonization may reduce the recurrences of the disease