Organic anion transporter:research advances / 国际药学研究杂志

Organic anion transporters(OAT)belong to a family of poly-specific transporters mainly locate in barrier epithelia such as renal proximal tubule.The solute transporter superfamily(SLC)is mainly distributed in the renal proximal convoluted tubules and located in other organs such as the brain,liver and placenta.They are mainly responsible for the reabsorption and secretion of en?dogenous and exogenous organic anions.OAT interact with endogenous metabolic end products such as urate and acidic neutrotransmit?ter metabolites,as well as a multitude of widely used drugs,and play an important role in the excretion and pharmacokinetics of drugs. This article reviews the recent progress in the research of the members of the OAT family.