Clinico-pathological findings in myeloid malignancies: a single center experience

Introduction: Myeloid malignancies are clonal disorders of hematopoietic stem/precursor cells. The criteria for the diagnosis of acute myeloid leukemia [AML] are based on morphological cytogenetic and flow-cytometric findings. The prognostic outcome with intensive chemotherapy is better than with non-intensive treatment

Purpose/Objectives: To determine the frequency of various clinical and pathological findings in myeloid malignancies

Study Design: Cross sectional descriptive study

Place and Duration of Study: The study was carried out at Department of Pathology from October 2014 to December 2016

Material/Patients and methods: Detailed history, clinical and pathological findings recorded on a pre-designed proforma including bone marrow reports was evaluated

Results: During period of study, 351 proformas including bone marrow reports were evaluated, from which 49 [30 males and 19 females; age ranges between 03 months to 60 years] were diagnosed as myeloid malignancies. The distribution of myeloid malignancies were acute myeloid leukemia [n=21], chronic myeloid leukemia [n=14], acute myelodysplastic syndrome [n=3], myeloproliferative neoplasms [n=3], myelofibrosis [n=2], myeloid hyperplasia [n=2], acute promyelocytic leukemia [n=2], myelomonocytic leukemia [n=1], ,and transient abnormal myelopoiesis [n=1].The main presenting complaints were fever and weight loss, whereas splenomegaly was the most common finding on clinical examination. The commonest laboratory finding was anemia followed by leukocytosis; while 10 patients showed pancytopenia

Conclusion: AML with fever and bicytopenia is the commonest myeloid malignancy in our series

Gartland's type iii supra condylar fracture of humerus in children treated with open reduction and internal fixation with cross K-wire fixation: a prospective study

To evaluate the short term results of open reduction and internal fixation with cross k-wires in type III supracondylar fracture of Humerus in children in our setup

PATIENTS and METHODS: This prospective study was conducted at Department of Orthopaedic Surgery and Traumatology, Liaquat University of Medical and Health Sciences, Jamshoro from March 2012 to March 2014. Total forty-seven patients with type III supracondylar Fracture Humerus were evaluated in this series. All were treated with open reduction and internal fixation with cross k-wires. The children followed regularly and the cosmetic and functional results assessed according to the Flynn criteria

RESULTS: The mean age in our series was 7.4 years. There were 35 boys and 12 girls

The most common mode of injury 72.34% was fall during play. In 95.75% of our cases injury was extension type and in 4.25% flexion type. Grade I pin tract infection was noted in only 3 patients. 69% cases have excellent cosmetic and functional results, 22% were having good cosmetic and functional results according to Flynn Criteria

CONCLUSION: Open reduction and internal fixation with cross k-wires produce excellent to good results in Gartland type III supracondylar fracture especially in the areas where image intensifier facilities are limited

Subtrochanteric femoral fractures treated by fixation with dynamic dondylar screw system

Objective: The purpose of this study was to evaluate the results of dynamic condylar screw system in the management of subtrochanteric femoral fractures, regarding union time, implant failure rate; infection rate and functional out come

Study Design: A prospective case series

Place and duration of study: This study was carried at the department of Orthopedic Surgery and Traumatology Liaquat university of Medical and Health, sciences Jamshoro, during January 2008 to December 2009

Material and Methods: Total 52 consecutive patients with subtrochanteric fracture were studied .Four patients were lost during follow-up and total 48 patients were finally assessed. The inclusion criteria was closed subtrochanteric fractures in adults of both gender aged 20 years or above; pathological fractures and open fractures were excluded from the study. After fixation of fractures with dynamic condylar screw system patients were followed -up for 6-12 months, the mean follow up period was 8 months. Results of treatment were assessed by the Radford criteria

Results: Among 48 studied cases, males were 29[60.42%] and female 19[39.58%]. Most common mode of injury was road traffic accidents in 32 patients [66.66%] and 16 patients had fall. All the patients underwent operative treatment by fixation of DCS. Autogenous bone graft was done in 07 patients. The union rate in this series was [93.5%]. Implant failure was observed in 03[6.25%] patients, 03 [6.25%] patients developed varus deformity and infection occurred in 02 [4.66 %]. According to criteria of Radford, we achieved good to excellent results in 81 % cases, fair in 6 [12.5 %] patients, poor in 03[6.25%0] patients

Conclusion: We conclude that subtrochanteric fractures need open reduction and internal fixation to avoid complications like implant failure, nonunion, infection, and mal-union. In our circumstances we achieve good results by the use of dynamic condylar screw