RESUMEN
Objective: To assess mid-luteal estradiol [E2] levels in poor and good responders and determine its effect on the outcome after intracytoplasmic sperm injection [ICSI]
Methods: The current study was carried out in females who underwent ICSI from June 2011 to September 2013 in "Islamabad Clinic Serving Infertile Couples". They were categorized into good and poor responders on the basis of female age 5, respectively. Their mid-luteal E2 measured on the day of embryo transfer was stratified into groups [A-E] on the basis of 20th, 40[th], 60[th] and 80[th] percentile values. The outcome was categorized into non-pregnant with beta human chorionic Gonadotrophin [hCG] 5-25 m IU/ml, and clinical pregnancy with beta hCG>25 m IU/ml
Results: The conception rate was 12% [63/513] in poor responders and 72% [237/329] in good responders respectively. The mid-luteal E2 levels were higher in conception as compared to non-conception cycles [p<0.001] in good and poor responders
Conclusion: Maximum pregnancies in poor and good responders [53% and 98% respectively] with mid-luteal E2 levels above 80th percentiles confirm the role of the increase in mid-luteal E2 for augmentation in conception rate of females after ICSI
RESUMEN
Background: The measurement of follicular output rate [FORT] has been proposed as a good indicator for evaluating follicular response to the exogenous recombinant folliclestimulating hormone [rFSH]. This places FORT as a promising qualitative marker for ovarian function. The objective of the study was to determine FORT as a predictor of oocyte competence, embryo quality and clinical pregnancy after intracytoplasmic sperm injection [ICSI]
Materials and Methods: This prospective study was carried out on a group of infer- tile females [n=282] at Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, from June 2010 till August 2013. Downregulated females were stimulated in injection gonadotropins and on ovulation induction day, pre-ovulatory follicle count [PFC] was determined using transvaginal ultrasound scan [TVUS], and FORT was determined as a ratio of PFC to antral follicle count [AFC]×100. Group I consisted of females with a negative pregnancy test, while group II had a positive pregnancy test that was confirmed with the appearance of fetal cardiac activity. Linear regression analyses of categorical variables of clinical pregnancy along with other independent variables, including FORT, were performed using SPSS version 15.0
Results: Pregnancy occurred in 101/282 women who were tested, recording a clinical pregnancy rate of about 35.8%. FORT values were higher in group II as compared to group I females [P=0.0001]. In multiple regression analysis, 97.7, 87.1, 78.2, and 83.4% variations were explained based on the number of retrieved oocytes per patients, number of metaphase II oocytes retrieved, number of fertilized oocytes, and number of cleaved embryos, respectively, indicating FORT as an independent predictor
Conclusion: FORT is a predictor of oocyte competence in terms of a number of retrieved, mature and fertilized oocytes. It also gives information about the number of cleaved embryos and clinical pregnancy rate
RESUMEN
To compare awareness and usage of various complementary alternative medicine [CAM] modalities in patients with asthma. An observational cross sectional study conducted at Pulmonology clinics on 452 male and female patients. Their age ranged from 10 till 50 years. An interview based questionnaire tested knowledge and use of CAM by intake of; tea, coffee, soups, joshanda, misri and honey, involvement by; yoga, swimming and breathing exercises along with application of CAM modalities like Vicks and steam inhalation. It was found that males had greater awareness and used modalities of CAM more than females. The age stratum reflecting maximum awareness was shown by the age group of 31-40 years with the females significantly having more knowledge[p= 0.01]. The knowledge was significant in patients who had family predisposition of seasonal allergies and had frequently been using inhalers. Application of CAM was seen with modalities of homeopathic and herbal medicines, coffee intake, steam inhalation, breathing exercises and use of multivitamins [p value<0.05]. The knowledge of use of swimming was found in 56%of asthmatics. A high ratio of respondents had knowledge of role of honey, soups, yoga exercises and application of Vicks vaporub but practices of these modalities were not found to be significant. Practice of swimming, intake of tea, soup/broth, honey; and application of Vicks was not found to be popular among patients with asthma. Patients with asthma were acquainted and used some adjuvants together with prescribed medicines as component of CAM; however its awareness was greater as compared to its usage