RESUMEN
OBJECTIVE: To study the effect of ethyl acetate extract of Songaricum Rupron (ECS) on ovariectomization induced learning and memory disorder in rats and its potential mechanism. METHODS: SD rats were ovariectomized to establish animal model of learning and memory disorder, and taken ECS by intragastric administration(3.3 mg · kg-1). Morris water maze was used to test the learning and memory ability of rats. HE staining was used to observe morphological change of hippocampal neurons. The p38 and p-CREB expression were tested by Western-Blot. RESULTS: The latent route of OVX + ECS group in the Morris water maze was significantly shorten, while numbers of crossing platform were markedly increased, compared with OVX group. The neurological form of pyramidal cells in hippocampus were improved by HE staining. CONCLUSION: It shows that the p38 expression is reduced while p-CREB is increased in OVX + ECS group, which potentially contributes to the improvement of learning and memory disorder due to lack of endogenous estrogen.