RESUMEN
Parkinson′s disease is the second major neurodegenerative disease with increasing incidence and population in China in recent years. Its diagnosis and treatment are difficult and there is no cure at present, which brings a heavy burden to the families of the patients and society. An accurate diagnosis of Parkinson′s disease is a prerequisite for treatment. The current diagnosis is mainly dependent on clinical symptoms. According to the diagnostic criteria in China, the diagnosis of Parkinson′s disease needs to go through the diagnosis of Parkinsonism and Parkinson′s disease. In addition, when the diagnosis of Parkinson′s disease is difficult, there are a number of ancillary tests that can be effective in the diagnosis and differential diagnosis of atypical Parkinson disease. With the progress of diagnostic technology, the diagnosis of Parkinson′s disease will become more standardized, intelligent and professional.
RESUMEN
Cognitive impairment is one of the most common non-motor symptoms of Parkinson′s disease, which is mainly related to abnormal protein deposition in related brain regions, impaired synaptic function, various transmitter system disorders and neuroimmune abnormalities. The incidence of Parkinson′s disease is relatively high, which seriously affects the quality of life of patients and imposes a heavy burden on society and families. At present, there are some early diagnostic markers in cerebrospinal fluid, peripheral fluid, gene and neuroimaging, which can be used for early warning and early recognition of cognitive impairment in Parkinson′s disease. Early warning and early diagnosis of cognitive impairment in Parkinson′s disease should be emphasized, and certain intervention and treatment can be carried out if necessary. Meanwhile, prospective, multicenter and large-sample high-quality clinical studies on cognitive impairment in Parkinson′s disease are needed urgently.
RESUMEN
AIM:To investigate whether propofol can alter the pulmonary inflammation induced by severe acute pancreatitis(SAP)in rats during its early period.METHODS:Seventy-two adult male Sprague-Dawley(SD)rats were randomly divided into nine groups with 8 animals in each group:sham group,SAP 30,60,120,360 min groups and propofol treatment 30,60,120,360 min groups.The preparation of SAP were induced by retrograde injection of 5% sodium taurocholate into the pancreatic duct of rats.And the treatment groups received propofol with doses of 150 ?g?kg-1?min-1 injected continually immediately in vena caudalis after the preparation of ASP were made.Rats were sacrificed at different time points,and the level of AMY and LIP,the wet dry weight ratio(W/D)of pulmonary and pancreatic tissue,the pathological change of pulmonary and pancreatic tissue were examined.RESULTS:Water content and pathological score of pulmonary tissue were decreased significantly within 360 minutes after reproduction of SAP were received propofol(both P0.05).CONCLUSION:propofol can alleviate pulmonary inflammation induced by severe acute pancreatitis in its early period.But propofol can not alleviate the injury of pancreatitis tissue.