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Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical consequences. Methods: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed at five hospitals. A total of 180 mild hospitalized patients with COVID-19 confirmed by PCR or chest image tests were enrolled and allocated to six arms including hydroxychloroquine 200 mg twice per day, placebo plus hydroxychloroquine 200 mg twice per day, single dose ivermectin (200 μg/kg), three low interval doses of ivermectin (200, 200, 200 μg/kg), single dose ivermectin (400 μg/kg), and three high interval doses of ivermectin (400, 200, 200 μg/kg). The primary endpoint of this trial was all-cause of mortality or clinical recovery. The radiographic findings, hospitalization and low O
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Background: Iodine is an essential element for growth and development and its inadequate intake leads to insufficient production of thyroid hormone. In developed countries iodine deficiency [ID] is one of the reformable factors. So, this study determined urinary iodine [UI] status of 8-10-year old school children in Yazd province during 2007 to 2016
Methods: This cross-sectional and descriptive study was conducted on 2236 students who were randomly selected from urban and rural regions with equal proportion of gender. Questionnaires were administered to gather the required descriptive data and then morning samples of urine were collected. Iodine concentration was determined with titration and acidic digestion. Data were analyzed through SPSS software
Results: During the study period, the percentage of students with UI of lower than 2 microg/dL, was zero and only 2.37 % of them had a UI level in the range of 2-4.90 microg/dL. Median of UI was 18.40 +/- 7.70 microg/dL level of UI in normal range showed noticeable increase from 2013 to 2016. Level of normal UI in ten years was 79.02%
Conclusions: According to the results of this study, Yazd province was considered "IDD free" similar to some other provinces. Also, level of UI more than 30 microg/dL was decreased. It is clear that this approaches need continuous evaluation such as annual evaluation of UI in 8-10 years old students at province level and every five years evaluation at national level
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Introduction and Aims: gastrointestinal cancers [GI] are considered as the most common cancer among men and are the second in women. The aim of this study was to evaluate the changes in crude and age specific incidence rates of gastrointestinal cancers in Neyshabur during 2006-2012
Materials and Methods: in this study the recorded data of Neyshabur's patients with cancer in the hospitals of Mashhad and Neyshabur were analyzed using Excel and SPSS v.16. Crude and age specific incidence rates were also estimated
Results: three hundred and thirty-five [42.8%] out of all 783 patients with cancer, were GI cancers. Gastric cancer showed the highest prevalence [41.8%] with the rate of 63.3 and 36.7 percent in men and women respectively. The results indicated the incidence of gastric cancer had a falling tendency
Conclusion: about half of all the cancers in Neyshabur are of the GI type and their incidence rate up to 2012 showed a decreasing trend so that, this rate is higher in men and older age groups. This decline may be due to numerous reasons such as control of risk factors, failure to identify eligible patients, referring to medical centers outside the province, or an increase in mortality and etc. that needs further investigation
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Fumonisins, a family of mycotoxins, are mainly found in wheat, corn and their products. Previous studies have shown that fumonisin B1 [FB1], the most abundant and toxic of known fumonisins, has been associated with many animal and human diseases including cancer. In the present study, the effects of FB1 were examined on the production of inflammatory cytokines in intestine and stomach cell lines. This study was performed in the Cancer Research Center of Tehran University of Medical Sciences in 2010. The cell lines of colon adenocarcinoma [SW742] and gastric epithelium [AGS] were purchased from the Pasteur Institute of Iran. The cells were pretreated with different concentrations of FB1 [0 to 100 micro M] for 3 days. The cells were later stimulated by lipopolysaccharides. Twenty-four hours after cell induction, the cytokines including tumor necrosis factor-alpha [TNF- alpha], interlukin-1 beta [IL-1 beta] and interlukin-8 [IL-8] were measured by ELISA. Treatment with FB1 induced a dose-dependent decrease in IL-8 production [P<0.05]. This decrease was seen in both SW742 and AGS cell lines. Moreover, FB1 induced a dose-dependent increase in the production of TNF- alpha and IL-1 beta in both cell lines [P<0.05]. The results of this study indicated that FB1 could increase the inflammatory cytokines including TNF- alpha and IL-1 beta in gastric and intestinal cell lines. These effects might result in the development of inflammatory responses and subsequent mucosal atrophy in in-vivo conditions