RESUMEN
The in vitro antibacterial activity of garlic against Helicobacter pylori [H.pylori] is well documented and the potential for its use in vivo was suggested. Garlic intake, a traditional habit by the Taskopru population in Turkey for decades, was examined for its effect on the prevalence of H. pylori and compared with the non garlic consuming group. Eighty-one garlic consuming asymptomatic subjects in Kastamonu province in Turkey [68 males, 13 females] of 23-82 years of age [average 46] were selected on a very restricted bases in regards to the garlic intake [raw or cooked, or both], amount, duration and other criteria. Control group [non-garlic consuming] of 81 asymptomatic subjects [66 males, 15 females] of 23-90 years of age [average 43] were enrolled for comparison with the garlic consuming group. Serum samples were collected from both groups during the period from September 2001 through to April 2002 and examined by the enzyme linked immunoassay test for anti H.pylori antibodies. An overall H.pylori prevalence of 79% and 81% was detected in the garlic and non garlic consuming groups. A significantly lower average antibody titer was detected in the garlic consuming group than that of the control group and similarly in those who consumed mixture of raw plus cooked garlic as compared to those who consumed raw or cooked garlic alone. Garlic intake for long durations [years] did not appear to have an effect on the prevalence of H.pylori infection. Garlic consuming subjects had a significantly lower average antibody titer than non garlic consuming groups, which might suggest an indirect inhibitory effect on the reproduction of H.pylori and possibly progression to more serious peptic ulcer diseases