Study of combination effects of nystatin and clotrimazole with some antibiotics on candida albicans

Binary combinations between 2 antifungal agents nystatin and clotrimazole and 4 antibiotics tetracyclines, chloramphenicol, rifampicin and gentamicin were tried using 7 Candida albicans strains isolated from clinical specimen using the checker board method. The best combinations were obtained with nystatin-tetracyclines and clotrimazole- gentamicin. However, synergistic activity between the 2 antifungal agents and these antibiotics was found only at high concentrations of the latter 500 ug - 125 ug/ml, thus limiting its application in vivo

In vitro synergistic activity of cefotaxime and netilmicin against pseudomonas aeruginosa strains

Twenty multiresistant Ps. aeruginosa strains were serotyped and subjected to a combination of two antibiotics, cefotaxime and netilmicin, using the Checker board broth dilution method, over a concentration ranging from 250 - 3.9 ug/ml. Synergism was observed between the two antibiotics against 18 of the 20 tested strains. The clinical significance of this in vitro synergy must be ultimately determined by carefully conducted comparative clinical trials

Antibacterial activity of staphylococcus aureus isolated from impetigo and non-impetigo cases

Screening of 56 S. aureus isolated from impetigo and 30 from non impetigo cases for their antibacterial activity as well as for hemolysin, lipase, lecithinase and DNase production was carried in this study. The antibacterial activity in both groups was mainly against micrococci and diphtheroids; being more pronounced in the impetigo group while hemolysis, lecithinase, lipase production were higher in the non impetigo group. The production of antagonistic substance in the impetigo group was encoded on a plasmid different from that responsible for the ampicillin resistance. In both groups, the active substance was found to be a protein of high molecular weight related to the bacteriocins. Such substances could be used as an epidemiological tool in rapid tracing of S. aureus strains in cases and carriers

Pathogenic properties of e coli isolated from urinary tract infection and faeces of normal subjects

This study was carried out on 39 urinary E. coli and 31 E. coli isolated from feces of normal individuals. Properties of E. Coli considered to be important in the pathogenesis of upper urinary tract infection were investigated. The properties which were found to be significantly more common in the urinary strains than in the fecal strains included production of hemolysin, pellicle formation, mannose sensitive hemagglutination and sensitivity to serum. On the other hand, no significant differences were found as regards sugar fermentation and sensitivity to urea and serine. Strains rich in the combination of these pathogenic properties were significantly more common among the urinary strains indicating that these properties might confer to them a greater ability to invade the urinary tract