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Objective To analyze the main causes of early neonatal death in Qingdao Women &Children's Hospital in the latest 10 years.Methods The medical records of early neonatal death in the Qingdao Women&Children’s Hospital from January 2002 through December 201 1 were analyzed.Results A total of 16 314 neonates were available to study,and 525 of them died.The mortality of early neonatal death within a week after birth was 77.71% (408 cases),including 214 premature infants and 194 mature infants.A comparison of mortality between the first 5-year and the second 5-year showed that the underlying trend of mortality was downward (P <0.05 ).The mortalities of early neonatal death within 1 day,3 days, and 4-7 days after birth were 1 10 cases (27.00%),192 cases (47.06%),and 106 cases (25.98%), respectively,and most of the neonates died within 3 days after birth;and the number of severe neonates died within 24 hours was higher than that in other two groups (P <0.01).The leading causes of early neonatal death in 10 years were:preterm birth-related factors (97 cases,23.78%),severe asphyxia (91 cases, 22.3%),congenital malformations (66 cases,16.2%).From 2002 to 2006,the top three main causes of early newborn death were severe asphyxia,congenital malformations and acute respiratory distress syndrome (ARDS),whereas from 2007 to 2011,the leading causes of death were ARDS,severe asphyxia,and congenital malformations.In comparison of early neonatal death between different gestational ages,preterm infants’death occurred mainly in 32 weeks,accounting for 26.72%.Conclusions In our hospital,the early neonatal mortality was decreased in the latest 10 years,and majority of deaths occurred within 3 days after berth,and preterm infants’death occurred mainly in 32 weeks.The leading causes of overall early neonatal death in order of frequency were premature birth,severe asphyxia and congenital malformations,but in later 5 years this order of leading causes changed.
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Objective To assess the incidences of intrauterine growth restriction (IUGR) and extrauterine growth restriction(EUGR) in premature infants with respiratory distress syndrome (RDS) and early nutritional efficiency on EUGR.Methods Data of 70 infants with RDS admitted in neonatal intensive care unit were reviewed.According to the weight when a premature infant was discharged,all subjects were divided into EUGR group(48 cases) and non-EUGR group(22 cases).The difference of two groups in terms of basic situation,peripartum factors,nutritional support,treatment measures and complications were compared.Results Assessing by weight,the incidence of IUGR and EUGR was 12.86％ (9/70)and 60.00％ (42/70)respectively.The differences in birth weight [(1 666.10 ±440.16) g vs (2 108.20 ±552.81) g],head circumference at birth [(28.81 ± 2.65) cm vs (30.48 ± 2.39) cm],IUGR,multiple pregnancy (16 cases vs 3 cases),cesarean delivery (29 cases vs 7 cases) were considered statistically significant (P ＜ 0.05),and there were no stastitically significant difference in gestational age,nutritional support,mechanical ventilation and complications (P ＞ 0.05).Conclusion The EUGR is related with IUGR,multiple pregnancy,cesarean delivery,low birthweight,low birth head circumference.The short time nutrition interventions can't improve EUGR in RDS.