Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
Braz. j. med. biol. res ; 27(5): 1225-1236, May 1994.
Artículo en Inglés | LILACS | ID: lil-319802

RESUMEN

1. Antibody specificity for the principal neutralization domain (PND) of the human immunodeficiency virus type 1 (HIV-1) was studied in plasma from 122 HIV-1-infected individuals residing in Brazil. 2. Using 8 overlapping sequential pentadecapeptides corresponding to the third variable region (V3) of 5 different HIV-1 isolates in an enzyme-linked immunosorbent assay (ELISA), a preferential recognition of the peptides with amino acid sequences corresponding to the HIV-1 isolates IIIB and MN (maximal reactivities of 60-70) compared to the isolates SC, WMJ-2 or RF (maximal reactivities below 60) was observed. 3. A difference was observed in the overall reactivity pattern to HIV-1 SC peptides of plasma collected from individuals residing in the Brazilian states of Rio de Janeiro and Bahia. However, a statistically significant increased recognition by Bahian plasma was only observed for the HIV-1 SC C55 peptide. 4. The mean CD4/CD8 ratio of the group of plasma with an isolate-restricted recognition of peptides (0.522 +/- 0.074) was significantly lower than that of the total group of plasma (1.00 +/- 0.18).


Asunto(s)
Humanos , Especificidad de Anticuerpos , VIH-1 , /inmunología , Región Variable de Inmunoglobulina/inmunología , Secuencia de Aminoácidos , Reacciones Antígeno-Anticuerpo , Brasil , Ensayo de Inmunoadsorción Enzimática , Datos de Secuencia Molecular , Fragmentos de Péptidos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA