RESUMEN
Nasal reactivity to histamine was determined in patients with perennial allergic rhinitis and in control subjects. A histamine titration method delivered by a metered dose pump was used. Stuffiness, itching, and the number of sneezes were recorded, nasal secretions measured, and nasal airway resistance was recorded by active anterior rhinomanometry. Increased nasal reactivity to histamine was observed among rhinitic patients and inversely correlated with the severity of nasal symptoms. A 3-fold increase of post-saline nasal airway resistance (NAR) best differentiated the nasal responses to histamine in rhinitic patients from those in control subjects. A histamine dose of < or = 2.5 microg provoked a 3-fold increase in NAR, strongly suggesting moderate or severe symptomatic rhinitis in most cases. Nasal provocation techniques might be a useful tool for objectively assessing disease severity and response to treatment in perennial allergic rhinitis.
Asunto(s)
Adolescente , Adulto , Niño , Femenino , Histamina/administración & dosificación , Humanos , Masculino , Persona de Mediana Edad , Mucosa Nasal/metabolismo , Obstrucción Nasal/diagnóstico , Pruebas de Provocación Nasal/métodos , Prurito/diagnóstico , Rinitis Alérgica Perenne/diagnóstico , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Estornudo/inmunologíaRESUMEN
Schirmer's test is not a reliable test to localize the level of facial nerve damage. From our results of Schirmer's test (greater than 30%), 53.3 per cent of the cases had facial nerve damage below the geniculate ganglion. Conservative treatment is recommended for delayed palsy.