Evaluation of lithium carbonate in treatment of bronchial asthma in children

The present work was designed to study the value of lithium carbonate in the long term therapy of asthmatic children and to measure the serum level of lithium in these patients after one month of treatment. No previous studies had measured serum lithium level in asthmatic children compared with healthy controls. There was significant difference in symptom score, PER and frequency of asthmatic attacks between placebo and lithium groups [only those receiving 20 mg/kg/day]

Liver functions in febrile children treated with some antipyretic drugs

This work is carried out on 45 febrile children from both sexes, their ages ranged from 3 - 12 years, with upper respiratory infection, they were divided into three equal groups. The 1[st] group treated with aspirin, the 2[nd] with acetaminophen, the 3[rd] with dipyrone in therapeutic doses. None of the cases had clinical features of hepatitis. Every child in the study was subjected to a thorough history taking, physical examination and measurement of serum transaminases [SGPT, SGOT], serum glutamyl transpeptidase [GGT] and prothrombin activity [PTA] were done before and after administration of each drug. The results revealed significant increase in SGPT, SGOT, GGT after administration of each drug accompanied with insignificant change in [PTA] in all cases The results obtained were discussed

study on the effect of salicylates on the liver functions during varicella infection

The effect of salocylates on the liver functions during varicells in fection and their relation to the pathogenesis of Reye's syndrome was studied in twenty cases of varicella taking aspirin and ten cases without aspirin therapy. The results showed mild elevation of SGPT, SCOT in the course of uncomplicated varicella infection. The normal levels of CGT would question but not exclude the hepatic origin of elevated transaminases. After aspirin, the increases in SGPT, SGOT and CGT was in boh varicella cases and control cases denoting that aspirin affects liver function, ans is one of the factors that result in Reye's syndrome

Evaluation of the combined therapy with Salbutamol and Beclomethasone inhalers in chronic severe Asthma in children

Study on 70 children with severe chronic asthma for the therapeutic effects of salbutamol [ventolin] inhaler followed by beclomethasone dipropionate [becotide] versus the effect of either inhaler alone was done. Four parameters were used to assess the state of asthma and to evaluate the efficacy of each regimen of treatment used. These were: the symptom score, frequency of asthmatic attacks, school off days and the peak expiratory flow rate measurements. The three regimens were found to be effective in controlling the disease in most patients. The combined therapy was more effective and more rapid. However, being more expensive, it should be restricted to patients not responding well enough to one of the 2 drugs alone