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@#Objective To explore the effect of pulmonary rehabilitation on activities of daily living(ADL)and pulmonary function in patients with chronic schizophrenia complicated with pulmonary infection at stable stage. Methods From January,2014 to July,2017,62 patients with chronic schizophrenia complicated with pulmonary infec-tion at stable stage were randomly divided into control group(n=31)and observation group(n=31).Both groups accepted routine medication,while the observation group received pulmonary rehabilitation for two months in ad-dition.The distance of 6-Minute Walk Test(6MWT),the modified Barthel index(MBI),modified British Medi-cal Research Council Dyspnea Scale (mMRC), C-reactive protein (CRP), Zung Anxiety Self-Rating Scale and Zung Depression Self-Rating Scale were compared before and after training. Results The total effective rate was higher in the observation group than in the control group(χ2=5.415,P=0.020).Com-pared with the control group,the distance of 6MWT increased(t=5.463,P=0.008),the score of MBI increased(t=2.142, P=0.028), the score of mMRC decreased (t=3.689, P=0.013), and the level of CRP decreased (t=-2.179,P=0.031)in the observation group.The scores of Zung Anxiety Self-Rating Scale(t=5.048,P=0.009) and Zung Depression Self-Rating Scale(t=-1.388,P=0.045)both decreased. Conclusion An early implementation of pulmonary rehabilitation could improve ADL and the exercise endurance,and reduce the incidence of infection in patients with chronic schizophrenia complicated with pulmonary infection at stable stage.
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In order to provide evidence for evidence-based medicine in the treatment and prognosis of laryngeal cancer in China,the meta-analysis electronically retrieved the case-control studies published in China about the Survivin expression and its association with clinical pathological features in the tissues of laryngeal carcinoma.The results showed that a total of 25 case-control studies were finally included with 1333 cases of laryngeal cancer and 528 cases of controls.The difference in the expression of Survivin between the two groups was statistically significant [OR=18.34,95％ CI (11.82,28.47),P＜0.00001].The difference in the expression of Survivin between laryngeal carcinoma patients with lymph node metastasis or not was statistically significant [OR=0.25,95％ CI (0.17,0.37),P＜0.00001].The expression of Survivin in clinical Ⅰ-Ⅱ stage group was significantly lower than in the clinical stage Ⅲ-Ⅳ group [OR=0.24,95％ CI (0.18,0.32),P＜0.00001].The expression of Survivin in patients with low/medium differentiation was significantly lower than that in those with high differentiation [OR=0.33,95％ CI (0.26,0.43),P＜0.00001].The difference in the expression of Survivin among different T stages of laryngeal carcinoma was statistically significant [OR=0.35,95％ CI (0.21,0.58),P＜0.00001].In conclusion,Survivin may play an important role in the occurrence and development of laryngeal carcinoma,and its high expression is related to the poor prognosis of patients with laryngeal cancer.