RESUMEN
Paraquat is a herbicide which is widely used by agricultural communities worldwide. It is extremely toxic for humans and ingestion of as less as 30 mL of 20%–24% concentration is usually lethal. The lack of an effective antidote is a concern due to the fatal outcomes associated with ingestion of paraquat. Herein, we are presenting a case of fatal paraquat poisoning in a young male from a center in India. The clinical course was complicated by liver, renal, and lung injury. We also describe its mechanism of toxicity, clinical features, and newer strategies being tried for treatment.
RESUMEN
Introduction : Acute Undifferentiated Fever (AUF) has a myriad of etiologies most common of which are Vector Borne Diseases in a country like India. The etiology and diagnosis of AUF is driven by the regional disease burden, seasonality of infectious diseases, spectrum and severity of disease, availability of diagnostics and access to health care facilities. Methods : A twelve-month prospective study was conducted at our centre to determine the commonly occurring causes of AUF. Monthly incidence of each of the common etiologies was noted and a graph was plotted to understand the seasonal distribution of each disease. Other parameters including age, gender, occupation and regional distribution were also studied. Results : The mean age (±SD) of the population in the present study was 33.16 (±15.88) years. Our study established that Scrub Typhus, Dengue fever and malaria were the most common reasons for AUF. The maximum incidence of AUF was between the months of June to October, peaking in the month of August. Urban population, younger age and males were more affected by AUF. Haryana followed by Punjab and Chandigarh had the highest regional burden of disease. Conclusion : It is imperative that we understand the seasonal and regional trends of AUF so that we can plan the resource allocation. Identifying the population at risk and timely intervention at Community level may help to reduce disease transmission.