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1.
Indian J Exp Biol ; 2001 Dec; 39(12): 1299-301
Artículo en Inglés | IMSEAR | ID: sea-58226

RESUMEN

The present study investigates the effects of a neurosteroid tetrahydrodeoxycorticosterone (5alpha-pregnan-3alpha-21-diol-20-one) in two experimental models of pain sensitivity in mice. Tetrahydrodeoxycorticosterone (2.5, 5 mg/kg, i.p.) dose dependently decreased the licking response in formalin test and increased the tail flick latency (TFL) in tail flick test. Bicuculline (2 mg/kg, i.p.), a GABA(A) receptor antagonist blocked the antinociceptive effect of tetrahydrodeoxycorticosterone in TFL test but failed to modulate licking response in formalin test. Naloxone (1 mg/kg, i.p.), an opioid antagonist effectively attenuated the analgesic effect of tetrahydrodeoxycorticosterone in both the models. Tetrahydrodeoxycorticosterone pretreatment potentiated the antinociceptive response of morphine, an opioid compound and nimodipine, a calcium channel blocker in formalin as well as TFL test. Thus, tetrahydrodeoxycorticosterone exerts an analgesic effect, which may be mediated by modulating GABA-ergic and/or opioid-ergic mechanisms and voltage-gated calcium channels.


Asunto(s)
Analgésicos/farmacología , Animales , Desoxicorticosterona/análogos & derivados , Masculino , Ratones , Receptores de GABA-A/antagonistas & inhibidores
8.
J Indian Med Assoc ; 1968 Feb; 50(3): 111 passim
Artículo en Inglés | IMSEAR | ID: sea-98665
9.
J Indian Med Assoc ; 1958 Jan; 30(1): 23-4
Artículo en Inglés | IMSEAR | ID: sea-97728

Asunto(s)
Sudoración
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