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1.
Journal of China Pharmaceutical University ; (6): 58-61, 2015.
Artículo en Chino | WPRIM | ID: wpr-811900

RESUMEN

@#To discover the novel compounds with biological activity, N-hetercycle substituted derivatives were synthesized based on the structure of benzofuran. A series of novel N-hetercycle substituted benzofuran derivatives(2a-2j)were synthesized by the reaction of 2-(4′-florobenzoyl)benzofuran with N-heterocyclic compounds. And the structures were characterized by 1H NMR, 13C NMR and HRMS. Their anti-tumor activities were studied in vitro against a panel of human tumor cell lines(HeLa, A549 and H1975)by the MTT assay. The results indicate that compounds 2a, 2f and 2j are the most potent within this series of compounds against human tumor cell lines, showing that they are promising lead compounds for further structural modifications and biological evaluation.

2.
China Journal of Chinese Materia Medica ; (24): 1111-1113, 2009.
Artículo en Chino | WPRIM | ID: wpr-263031

RESUMEN

<p><b>OBJECTIVE</b>To investigate the flavonoids in leaves of Alstonia scholaris, an ethno-remedy of Dai People in Yunnan.</p><p><b>METHOD</b>The chemical constituents were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic evidences and physicochemical properties.</p><p><b>RESULT</b>Eight flavonoids were isolated and identified as kaempferol (1), quercetin (2), isorhamnetin (3), kaempferol-3-0-beta-D-galactopyranoside (4), quercetin-3-0-beta-D-galactopyranoside (5), isorhamnetin-3-0-beta-D-galactopyranoside (6), kaempferol-3-0-beta-D-xylopyranosyl-( 2-1)-0-beta-D-galactopyranoside (7) ,quercetin-3-0-beta-D-xylopyranosyl-( 2-1)-0-beta-D-galactopyranoside (8).</p><p><b>CONCLUSION</b>Flavonoids 1-7 were isolated from A. scholaris for the first time.</p>


Asunto(s)
Alstonia , Química , Flavonoides , Hojas de la Planta , Química
3.
Chinese Traditional and Herbal Drugs ; (24)1994.
Artículo en Chino | WPRIM | ID: wpr-579694

RESUMEN

Objective To study the chemical constituents of the Dai ethno-medicine Rhinacanthus nasutus.Methods The chemical constituents had been spearated with chromatography and their structures were determined by spectral analyses.Results Nine compounds and two mixture were isolated and identified as C26—C32 alkyl mixture(Ⅰ),?-monopalmitin(Ⅱ),palmitic acid(Ⅲ),stearic acid(Ⅳ),lignoceric acid(Ⅴ),?-sitosterol(Ⅵ),lupeol(Ⅶ),p-hydroxy benzoic acid(Ⅷ),daucosterol(Ⅸ),?-ethyl-D-idosopyranoside(Ⅹ),and mixture of KNO3 and NaNO3(Ⅺ).Conclusion Compound Ⅹ is a new artificial compound during isolation and compounds Ⅰ—Ⅴ,Ⅷ—Ⅺ are isolated from R.nasutus for the first time.

4.
Chinese Traditional and Herbal Drugs ; (24)1994.
Artículo en Chino | WPRIM | ID: wpr-573831

RESUMEN

Objective To provide basis for choosing a proper processed method of Polygonum multiflorum.Methods To compare and analyze main active component changes in the processed products of P.multiflorum by being steamed without any adjuvants and with soya-bean milk of different concentrations.Results There was no marked difference for variously processed products in the main active components,anthraquinone and stilbene glucoside in P.multiflorum.Conclusion It is feasible to replace the steamed with soya-bean milk by the steamed without any adjuvants.

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