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J. oral res. (Impresa) ; 7(6): 232-235, ago. 1, 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1120975

RESUMEN

Objective: to compare the gene expression levels of collagen type I alpha 2 (COL1A2) in children with and without dental fluorosis. methods: cross-sectional study involving 92 children between 5 and 12 years of age. socio-demographic characteristics, the presence of dental fluorosis by means of the Thylstrup-Fejerskov index, and gene expression analysis of COL1A2 in peripheral blood samples by reverse transcription polymerase chain reaction (RT-PCR) assays, were described. for the descriptive analysis, measures of central tendency, dispersion and proportions were used. differences between the groups (p<0.05) were established by the student t-test. results: mean age was 8.6 (SD=1.9) years, 51.1 percent were female; 54 children were diagnosed with fluorosis and 38 without fluorosis; prevalence of dental fluorosis was 58.7 percent (95 percent CI: 48.4 percent -68.9 percent). gene expression of COL1A2 was statistically significantly lower (p<0.05) in the participants with dental fluorosis. conclusion: there are differences in the expression levels of the COL1A2 gene among the population under study. therefore, COL1A2 may be potentially involved in the development of dental fluorosis.


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Niño , Colágeno Tipo I/fisiología , Fluorosis Dental/etiología , Expresión Génica , Regulación de la Expresión Génica/fisiología , Estudios Transversales , Colombia/epidemiología
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