RESUMEN
OBJECTIVES: Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. METHOD: Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons. RESULTS: The results were as follows 1) When genotypes of apolipoprotein E were classified into epsilon2/2, epsilon2/3, epsilon2/4, epsilon3/3, epsilon3/4, epsilon4/4 according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups CONCLUSION: These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.
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Humanos , Alelos , Apolipoproteínas , Frecuencia de los Genes , Genotipo , Fenotipo , Reacción en Cadena de la Polimerasa , Polimorfismo Genético , EsquizofreniaRESUMEN
OBJECTIVE: The authors report the operative methods and postoperative outcomes of 14 cases with intractable supplementary sensorimotor area(SSMA) seizures. METHODS: From September 1996 to July 2001, 14 intractable cases treated by operation were reviewed and analysed with the help of each clinical characteristics, magnetic resonance images, histopathologic findings, noninvasive and invasive electroencephalographies(EEG), subdural grid and strip insertion and intracranial electrocorticographies and brain mapping results, retrospectively. The follow-up duration was from 2 months to 70 months(average, 26 months). RESULTS: There were eight males and six females and the age ranged from 2 to 47 years(average, 26.2). In the MRI findings, six lesional and eight nonlesional cases, and there were six localized and eight lateralized cases in the semiology and noninvasive EEG studies. In the histopathologic findings, cortical dysplasia was eight cases, gliosis three cases, leukomalacia one case and normal finding was two cases. In the seizure outcome, Engel's class I was 71.4%, class II was 21.4% and class III was 7.2%. The postoperative neurologic deficits were 12 in 14 cases and nine in 12 cases were dramatically improved within two or three weeks postoperatively and the remained three cases, the lesion was involved in the eloquent area but, all of them were improved via the rehabilitation programs. CONCLUSION: In the intractable SSMA seizure, the surgical treatment is an excellent method of treatment and early transient postoperative neurologic deficits were dramatically improved within several weeks.
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Femenino , Humanos , Masculino , Mapeo Encefálico , Electroencefalografía , Estudios de Seguimiento , Gliosis , Imagen por Resonancia Magnética , Malformaciones del Desarrollo Cortical , Manifestaciones Neurológicas , Rehabilitación , Estudios Retrospectivos , ConvulsionesRESUMEN
A boy since 6 years of his age who have had complex partial seizure was referred to our Department in March 1998. The left anterior temporal lobectomy with the resection of the head and body of hippocampus and gross total tumor removal was also performed in April 1998. He has been seizure free and stable about 3 years postoperatively. In January 2001, he revisited us due to headache, nausea, and vomiting from one week before. MRI revealed recurrence of the tumor, and a partial removal of the tumor was performed. Nine months from the second operation, the tumor recurred again and the thrid operation was followed. The pathologic findings were dysembryoplastic neuroepithelial tumor (DNT) in all three cases and no evidences of anaplastic changes were found in two recurrent cases. In general, DNT is known to be a disease that rarely transforms into the malignant, postoperative adjuvant radio-or chemotherapy is unnecessary even after partial resection of the tumor. However, in our case, there were two episodes of recurrence after the total resection. Here, we report the first case of recurrent DNT even after the total resection within three years in our knowledge.
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Humanos , Masculino , Lobectomía Temporal Anterior , Quimioterapia , Cabeza , Cefalea , Hipocampo , Imagen por Resonancia Magnética , Náusea , Neoplasias Neuroepiteliales , Recurrencia , Convulsiones , Lóbulo Temporal , VómitosRESUMEN
Three beagle dogs aged over one and half years were used in this study. All mandibular premolars were carefully extracted. Two AVANA implants(Sumin, Korea) and two 3i implants(Implant Innovation, USA) were installed at each right and left side respectively. Each dog was sacrificed at 4, 8. 12 weeks. Non-decalcified specimens were made and stained for a light microscopic study. The results were as follows; 1. Inflammation was not observed in the area of bone tissue adjacent to the implant body. 2. With time, quantity of osseointegration increased in each type of dental implant. There was no difference between AVANA implant and 3i implant. 3. Maturation of the bone around each type of the dental implant increased with time. 12 weeks after implant installation, the bone around dental implant represented compact bone-like appreance. 4. In case implants were located adjacent to a root, newly-formed periodontal ligament tissue was observed around the implant. And the direction of the periodontal ligament fiber was parallel to the surface of the implant. Within the results of this study, AVANA implants represented similar osseointegration in comparision with 3i implants.
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Perros , AnimalesRESUMEN
BACKGROUND AND OBJECTIVES: Hypothyroidism is a well recognized complication of radiotherapy and surgery in the treatment of head and neck cancer, especially laryngo-hypopharyngeal cancer. Several studies were undertaken to determine the thyroid stimulating hormone (TSH) levels in the population of patients with head and neck cancer, to better characterize clinical factors in the eventual elevated TSH levels. We evaluated the incidence and related factors of hypothyroidism following radiotherapy, surgery and combined treatment for laryngeal and hypopharyngeal cancer. MAERIALS AND METHODS: Forty-four patients who had been treated for laryngeal and hypopharyngeal cancer were divided into three groups according to the types of treatment they received: radiotherapy alone, surgery with partial thyroidectomy, surgery with partial thyroidectomy and postoperative radiotherapy. TSH and free thyroxin (T4) level were examined before and after the treatment. We analyzed the differences according to clinical factors and treatment modalities. RESULTS: The TSH level was higher in hypopharyngeal cancer than in laryngeal cancer (p>0.05). In the advanced stage and during longer follow-up periods, the TSH level were elevated (p<0.05). In patient with combined treatment modalities, the TSH level was higher than in patients who received radiotherapy or surgery alone (p<0.05). CONCLUSION: We concluded that hypothyroidism frequently develops following treatment for laryngeal and hypopharyngeal cancer even when thyroid resection has not been performed. Patient should be evaluated postoperatively and carefully monitored by means of serial thyoid function test.
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Humanos , Estudios de Seguimiento , Neoplasias de Cabeza y Cuello , Neoplasias Hipofaríngeas , Hipotiroidismo , Incidencia , Neoplasias Laríngeas , Radioterapia , Pruebas de Función de la Tiroides , Glándula Tiroides , Tiroidectomía , Tirotropina , TiroxinaRESUMEN
PURPOSE: To evaluate the MR findings of gestational trophoblastic tumor(GTT) in correlation with pathological results. MATERIALS AND METHODS: Nine patients who confirmed the diagnosis (four choriocarcinomas and five invasive moles) constituted the basis of our study. Pathologic specimens were taken from the tumors corresponding to the regions of interest on MR images. The MR images were analyzed in respect of the morphology and signal intensity of the tumors, uterine and adnexal vascularity, and the adnexal lesion. RESULTS: The MR findings of four choriocarcinomas were well-defined, hemorrhagic masses with central necrosis;the masses were hyperintense on Tl-weighted images. In contrast, the five invasive moles showed irregular and permeative masses with densely enhanced solid components and tiny cystic lesions. The trophoblastic proliferation, coagulation necrosis, and molar villi had variable signal intensities on Tl-and T2-weighted images. CONCLUSION: Our results suggest that MR imaging is a promising tool for noninvasive morphologic analysis of GTTS.
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Femenino , Humanos , Embarazo , Coriocarcinoma , Diagnóstico , Mola Hidatiforme Invasiva , Imagen por Resonancia Magnética , Diente Molar , Necrosis , Neoplasias Trofoblásticas , TrofoblastosRESUMEN
No abstract available.
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Embarazo , Velocidad del Flujo Sanguíneo , Arterias UmbilicalesRESUMEN
No abstract available.