[Autoimmune thyroid disease. Clinical and biological correlations]

In this article, we analyze the clinical and biological data concerning the autoimmune thyroid diseases in patients recruited in an endocrinology clinic at the university hospital center of Hotel-Dieu de France between March 2005 and November 2005. We studied 121 patients [51 with Basedow disease and 70 with Hashimoto thyroiditis], between 13 and 68 years old, with a BMI of 24.68 kg/m[2] and with a female predominance [105 women]. Symptoms of hyperthyroidism represented the most frequent cause of consultation. The distribution of patients regarding their thyroid disease showed that 42.1% of patients had hyperthyroidism [only one patient had subclinical hyperthyroidism], 21.5% had a subclinical hypothy-roidism, 28.1% had clinical hypothyroidism and 83% had euthyroid goiter. Half of the patients had at least a member of their family whith a thyroid disease. The autoimmune thyroid diseases are strongly associated to other autoimmune diseases and to repetitive spontaneous abortion. Thus, 39% of the married women had had at least one spontaneous abortion and 26.4% of the patients had one or more autoimmune disease associated to their thyroid disease; diabetes mellitus type 1 representing the most frequent one. Concerning the treatment, we remarked a remission of 30 patients [66.7%] with Basedow disease after 18 months of anti-thyroid drug treatment of 45 patients. In Hashimoto thyroiditis, we remarked a frequent evolution of patients with subciinical hypothyroidism to overt hypothyroidism when medical treatment was not initiated

Adenopathie cervicale revelatrice de microcancer papillaire de la thyroide

Aim of the study to report retrospectively 5 cases of papillary M inicrocarcinoma of the thyroid revealed by cervical adenopathy with the clinic and histologic characteristics. material and method: Total thyroidectomy and bilateral cervical lymphadenectomy was realized in 5 patients From 1996 to 2002, 4 females and one man of 33 years old mean age presented for cervical adenopathy. Biopsy confirmed thyroid metastatic nature. The final pathology showed: a papillary microcarcinoma, bilateral and multifocal in 4 patients [80%], bilateral adenopathy in 3 patients [60%]. All patients had a radioactive iodine and hormonotherapy postoperatively. The follow-up varied from 12 to 30 months. No metastasis or local recurrence were noted Total thyroidectomy and bilateral cervical lymphadenectomy is the treatment of choice for papillary microcarcinoma of the thyroid presenting as a cervical metastatic adenopathy because it was bilateral and multifocal in 80% of cases with bilateral positive adenopathy in 60% of cases. Radioactive iodine and hormonotherapy postoperatively are recommended