RESUMEN
A comparative study of the treatment of non-specific vaginitis was carried out in order to compare the efficacy of the use of tetracycline and thiamphenicol among women attending the sexually tranamitted disease clinic of the Department of Obstetrics and Gynaecology, Siriraj Hospital. The inclusion criteria included women with abnormal vaginal discharge having a pH of 5 or more but in whom the presence of Trichomonas vaginalis, Candina albicans or Neisseria gonorrhoea was not observed. Eighty-one women were enrolled in this study and were randomly categorized into two groups, i.e. the tetracycline treatment group and the thiamphenicol treatment group. Two grams of each drug were given orally for seven consecutive days to the women in the respective groups. In this study, vaginal discharge was cultured for Gardnerella vaginalis, Chlamydia trachomatis and for aerobic bacteria; the growth of G. vaginalis and C. trachomatis was encountered in 71.6 and 12.35 percent of the cultured, respectively. The cure rate achieved with tetracycline was 82.93 percent while that of thiamphenicol was 97.5 percent. In this study equal dosage of thiamphenicol yielded a significantly (P=.028) better result than tetracycline in the treatment of non-specific vaginitis with regard to improvement of signs and symptoms. No adverse side-effect was encountered in either treatment group.