RESUMEN
Thymomas are associated with various autoimmune disorders in adults, most commonly with myasthenia gravis (MG). In MG antibodies developed against acetylcholine (ACh) receptors, resulting weakness of muscle after repeated use and recovery following a period of rest. However, MG due to thymoma is extremely rare in pediatric age group.1We report an infant with MG due to invasive thymoma.
Asunto(s)
Biopsia con Aguja , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Lactante , Masculino , Miastenia Gravis/complicaciones , Miastenia Gravis/diagnóstico por imagen , Miastenia Gravis/terapia , Medición de Riesgo , Índice de Severidad de la Enfermedad , Timectomía/métodos , Timoma/complicaciones , Timoma/diagnóstico por imagen , Timoma/cirugía , Neoplasias del Timo/complicaciones , Neoplasias del Timo/diagnóstico , Neoplasias del Timo/cirugía , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
We present two cases where GS was sole presentations, months before the diagnosis of AML.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biopsia con Aguja Fina , Médula Ósea/patología , Niño , Progresión de la Enfermedad , Resultado Fatal , Humanos , Inmunohistoquímica , Leucemia Mieloide Aguda/tratamiento farmacológico , Leucemia Mieloide Aguda/etiología , Leucemia Mieloide Aguda/patología , Masculino , Invasividad Neoplásica/patología , Medición de Riesgo , Sarcoma Mieloide/complicaciones , Sarcoma Mieloide/tratamiento farmacológico , Sarcoma Mieloide/patología , Tomografía Computarizada por Rayos X , Negativa del Paciente al TratamientoRESUMEN
We report a case of systemic onset juvenile idiopathic arthritis (SOJIA), the manifestations of which started with fever and skin rash followed by arthritis within neonatal age. Such presentation is extremely rare in the newborn. After exclusion of closely mimicking conditions like congenital infections, neonatal onset multisystem inflammatory disease (NOMID), neonatal; lupus erythematosus (NLE) diagnosis of SOJIA may be entertained even in a neonate where arthritis, fever and rash are the presenting features.
Asunto(s)
Artralgia/diagnóstico , Artritis Juvenil/diagnóstico , Diagnóstico Diferencial , Quimioterapia Combinada , Exantema/diagnóstico , Fiebre/fisiopatología , Estudios de Seguimiento , Humanos , Ibuprofeno/administración & dosificación , Lactante , Dimensión del Dolor , Medición de Riesgo , Índice de Severidad de la Enfermedad , Esteroides/administración & dosificación , Resultado del TratamientoRESUMEN
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disorder of the childhood and is manifested by synovitis with or without systemic features. Secondary vasculitis occurring in response to JIA is reflected clinically on different structures or systems of the body. Here is reported a rare case of systemic onset JIA (SOJIA) with vasculitis leading to peripheral gangrene.
Asunto(s)
Amputación Quirúrgica , Antirreumáticos/uso terapéutico , Artritis Juvenil/complicaciones , Preescolar , Pie/irrigación sanguínea , Gangrena/etiología , Humanos , Ibuprofeno/uso terapéutico , Masculino , Prednisolona/uso terapéutico , Vasculitis/etiologíaRESUMEN
Systemic lupus erythematosus (SLE) is a multisystem immunologic disease. Renal and neurological manifestations are frequently seen in childhood SLE. Out of the neurological features movement disorders are uncommon. A case of SLE is presented here with unusual neurological manifestation i.e. chorea associated with microphonia.
Asunto(s)
Niño , Corea/etiología , Femenino , Humanos , Lupus Eritematoso Sistémico/complicaciones , Trastornos del Habla/etiologíaRESUMEN
Two cases of Wilson's disease with unusual features are reported. In one case neurological abnormality was the presenting feature without any clinical involvement of the liver. In the other case, neurologic manifestations were associated with rickets and cholelithiasis, a result of chronic hemolytic state. Apart from clinical profile both the cases were diagnosed by grossly reduced serum ceruloplasmin level. However, Kayser-Fleischer rings were found in each case.