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Rev. méd. Chile ; 135(3): 335-340, mar. 2007. ilus, tab
Artículo en Español | LILACS | ID: lil-456619

RESUMEN

Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim: To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material and Methods: Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. Results: The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids. Conclusions: In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak.


Asunto(s)
Adolescente , Niño , Humanos , Anticonvulsivantes/análisis , Carbamazepina/análisis , Epilepsia/metabolismo , Saliva/química , Anticonvulsivantes/sangre , Anticonvulsivantes/uso terapéutico , Carbamazepina/sangre , Carbamazepina/uso terapéutico , Monitoreo de Drogas , Epilepsia/sangre , Epilepsia/tratamiento farmacológico , Proyectos Piloto
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