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Objetivo: Avaliar os níveis séricos de colesterol total em indivíduos atendidos em um laboratório universitário de análises clínicas, localizado em Erechim, RS. Métodos: Níveis de colesterol total foram obtidos a partir de uma análise retrospectiva transversal com indivíduos de ambos os sexos e idade entre 20-79 anos, entre 2010 a 2013. Resultados: Os níveis de colesterol total de 1.475 pacientes, incluindo 479 homens e 996 mulheres, foram analisados. Na população feminina, 46,89% das participantes apresentaram valores normais de colesterol total, e este índice para a população masculina correspondeu a 50,31%. Foi encontrada uma correlação significativa entre a idade e o colesterol total nos participantes do sexo feminino (p=0,019). Em ambos os sexos foi observado um aumento nos níveis de colesterol total durante as primeiras décadas de vida, seguido por estabilização a partir da quinta e sexta décadas de vida, respectivamente para homens e mulheres. Conclusão: A prevalência de hipercolesterolemia foi elevada na população do estudo, o que indica a necessidade de apropriadas estratégias de intervenção para profilaxia de risco cardiovascular
Objective: To estimate the prevalence of hypercholesterolemia amongadults attended in a university laboratory, localized in Erechim/RS. Methods: Cholesterol total levels were obtained from s transversal retrospective analysis with individuals of both genders and age between 20-79 years, from 2010 to 2013. Results: The total cholesterol levels of 1.475 patients, including 479 men and 996 women were analyzed. In female gender 46.89% of participants showed normal total cholesterol levels, and this value in masculine population corresponded to 50.31%. Was found a significantly correlation between age and total cholesterol in female participants (p=0.019). In both genders was observed a increase in total cholesterol levels during the first life decades, followed by stabilization from fifth and sixth life decade, respectively for men and women. Conclusion: The prevalence hypercholesterolemia was high in study population, which necessitates appropriate intervention strategies to prevent cardiovascular risk.
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Estudios Epidemiológicos , Prevalencia , Dislipidemias , ColesterolRESUMEN
ABSTRACT Introduction: Candidemia is a bloodstream infection produced by Candida genus yeasts. Objective: The purpose of this study was to characterize the epidemiology and the fluconazole susceptibility in Candida species isolated from patients at a regional hospital in Passo Fundo, RS. Methods: Records from the laboratory were used to identify patients with positive blood cultures for Candida between 2010 and 2011. The in vitro activity of fluconazole was determined using the disk diffusion method. Results: Were analyzed 24 positive blood cultures for Candida and found a 54.16% mortality rate. C. albicans was the most prevalent species, followed by C. parapsilosis and C. krusei. For susceptibility to fluconazole, C. albicans, C. parapsilosis and C. tropicalis showed 100% sensitivity. However, C. krusei was 100% resistant; and C. glabrata, 50% resistant. Conclusion: The high mortality and fluconazole resistance rates emphasize the importance of the diagnosis of candidemia in a hospital environment. .
RESUMO Introdução: Candidemia é a infecção da corrente sanguínea produzida por leveduras do gênero Candida. Objetivos: Este estudo teve por objetivo caracterizar a epidemiologia e o perfil de suscetibilidade ao fluconazol em espécies de Candida, isoladas em pacientes internados em um hospital regional de Passo Fundo, RS. Métodos: Registros laboratoriais foram utilizados para identificar pacientes com hemocultura positiva para espécies do gênero Candida, entre 2010 e 2011. A atividade in vitro do fluconazol foi determinada por meio do método de difusão em disco. Resultados: Foram analisadas 24 hemoculturas positivas para Candida; a taxa de mortalidade encontrada foi 54,16%. C. albicans foi a espécie mais prevalente, seguida por C. parapsilosis e C. krusei. C. albicans, C. parapsilosis e C. tropicalis apresentaram 100% de sensibilidade ao fluconazol, entretanto C. krusei mostrou-se 100% resistente; e C. glabrata, 50% resistente. Conclusão: A elevada taxa de mortalidade e resistência ao fluconazol enfatiza a importância do diagnóstico de candidemia em ambiente hospitalar. .
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Ilex paraguariensis is a native species to South America. Its economic importance is in the use of its leaves and twigs in the processing of a product popularly known as "chimarrão". The aim of this study was to evaluate the correlations between some physico-chemical process parameters in the oxidation of I. paraguariensis leaves oxidation. The leaves of Maté with age 1.0, 6.5 and 12.0 months were subjected to an oxidation process for 3 h under different relative humidity conditions (80, 90 and 99%) at 26°C. The extracts were evaluated using the experimental design techniques to maximize the oxidation conditions for the total polyphenols, antioxidant capacity, water activity and color. The condition of 90% humidity and leaf age 6.5 months resulted in lower lightness and yellow color of the product. Green color was not significantly influenced by the studied parameters. The highest levels of total phenols and antioxidant potential were found when the leaf age was one month and humidity was 90%. Thus, it could be concluded that the air humidity of the chamber and leaf age influenced the oxidation process of the leaves of Maté as well as the antioxidant capacity of the extract obtained.
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In Brazil, yerba mate is consumed after processing; however, in Chile and Uruguay, the consumers prefer the cured product, which acquires a yellow color. For that yerba-mate is stored for a period of six months to one year, which increases the cost of the final product for the overseas market. This study evaluated the effect of humidity and temperature in maturation chamber on the time required for the product to get this characteristic. The changes in the color, pH, moisture and water activity were evaluated during the time of storage in different conditions of temperature and humidity. Yerba-mate subjected to higher temperature and humidity showed nearest color of the product submitted to natural storage. The loss of green color was related to the reduction in pH and increase in the moisture of the samples. The higher humidity allowed the mate to reach conditions near to market requirements abroad in approximately 60 days of maturation.
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Nontuberculous mycobacteria are etiologic agents of opportunistic human infections. Although they usually affect superficial tissues, infections in bones and joints have been described. The contamination is associated with increased environmental exposure. With appropriate therapy, the cases usually progress to complete recovery of the patient. This study reports the case of a patient who developed a cutaneous nodule in her left foot acquired when her skin was punctured by a fish. The anatomopathological examination revealed chronic central suppurative granulomatous dermo-hypodermal inflammation. Furthermore, the screening for resistant acid-fast bacilli was positive.
Micobactérias não tuberculosas são agentes causadores de infecções oportunistas no homem. Embora, geralmente, afetem tecidos superficiais, infecções em ossos e articulações têm sido descritas. O contágio está associado ao aumento da exposição do homem ao meio ambiente. Diante da terapêutica adequada, os casos normalmente evoluem com recuperação total do indivíduo. Este estudo descreve o caso clínico de um paciente que apresentou nódulo cutâneo no pé esquerdo após traumatismo com um peixe. O exame anatomopatológico revelou inflamação crônica granulomatosa centralmente supurativa dermo-hipodérmica e a pesquisa de bacilos álcool-ácido resistentes (BAAR) foi positiva.