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Mem. Inst. Oswaldo Cruz ; 105(6): 818-822, Sept. 2010. ilus
Artículo en Inglés | LILACS | ID: lil-560669

RESUMEN

This study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishmania chagasiinfection. These immunogenic preparations were composed of Leishmania amazonensisor Leishmania braziliensisantigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challenged with promastigotes of L. chagasiby intravenous injection. We observed that both vaccine candidates induced a significant reduction in the parasite load of the liver, while the L. amazonensisantigenic extract also stimulated a reduction in spleen parasite load. This protection was associated with a suppression of both interleukin (IL)-10 and IL-4 cytokines by spleen cells in response to L. chagasiantigen. No change was detected in the production of IFN-γ. Our data show that these immunogenic preparations reduce the type 2 immune response leading to the control of parasite replication.


Asunto(s)
Animales , Femenino , Ratones , Antígenos de Protozoos/inmunología , /biosíntesis , /biosíntesis , Vacunas contra la Leishmaniasis/inmunología , Leishmaniasis Cutánea/inmunología , Antígenos de Protozoos , /inmunología , /inmunología , Leishmania braziliensis/inmunología , Leishmania infantum/inmunología , Leishmania mexicana/inmunología , Leishmaniasis Cutánea , Leishmaniasis Cutánea , Hígado , Ratones Endogámicos BALB C , Saponinas , Saponinas/inmunología , Bazo
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