RESUMEN
Objective To explore the effect of tonifying kidney with traditional Chinese medicine together with estradiol valerate and clomiphene citrate on serum leptin levels in patients with polycystic ovarian syndrome. Method Two hundred and eight patients with PCOS were randomly divided into observation group (n=104) and control group (n=104). Patients in control group and observation group took estradiol valerate and clomiphene citrate, while patients in observation group took Shiying Minlin soup for three months. Crinosity, body temperature, acne&Skin diseases, and menoxenia were recorded; Leptin (LP) and five hormone including follicle stimulating hormone (FSH),luteinizing hormone (LH), prolactin (PRL), estradiol (E 2) and testosterone (T) are determined using euzymelinked immunosorbent assay. Results Crinosity, body temperature, acne&Skin diseases, and menoxenia were improved;the level of FSH, LH, PRL, E 2, T in both observation and control group decreased and the content in observation group are high than that in control group, while LH,T and E 2 are lower. Conclusion Treatment with tonifying kidney with traditional Chinese medicine on polycystic ovarian syndrome can decrease the level of FSH, LH, PRL, E 2, T and LP. Compared with western medicine, tonifying kidney with traditional Chinese medicine showed advantage in the terms of treatment on polycystic ovarian syndrome.