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1.
Chinese Journal of Preventive Medicine ; (12): 538-541, 2013.
Artículo en Chino | WPRIM | ID: wpr-355827

RESUMEN

<p><b>OBJECTIVE</b>To study the association of polymorphisms in the potassium voltage-gated channel, KQT-like subfamily,member 1(KCNQ1) gene with type 2 diabetes in Chinese population from Jiangsu province.</p><p><b>METHODS</b>Subjects consisting of 2925 cases and 3281 controls were enrolled from a community based cohort study of type 2 diabetes in Wuxi in 2007 and a community based cross-sectional survey on chronic non-communicable disease in Nantong in 2009. Epidemiological questionnaire survey and physical examinations were conducted and 10 h overnight fasting blood samples of 5 ml were drawn for all subjects.Genotypes were determined by TaqMan OpenArray Genotyping System and i-PLEX Sequenom MassARRAY platform. The relationship between KCNQ1 gene polymorphism and risk of type 2 diabetes after adjustment for age,sex and body mass index (BMI) was analyzed.</p><p><b>RESULTS</b>The C allele of rs2237897, rs2237892 and rs2237895 at KCNQ1 increased the risk of type 2 diabetes with adjusted OR (95%CI) value being 1.41(1.30-1.54), 1.35(1.24-1.47), 1.22(1.12-1.33) respectively (all P value < 0.05) under the additive genetic model after adjusted by age,sex and BMI. Stratification analyses in additive genetic model showed that the C allele of rs2237897 increased the risk of type 2 diabetes in subgroups stratified by age ( ≤ 56 years and > 56 years), sex (females and males), BMI (< 24 kg/m(2) and ≥ 24 kg/m(2)) with OR (95%CI) value being 1.39(1.22-1.59), 1.43(1.28-1.60), 1.40(1.26-1.55), 1.44(1.26-1.66), 1.48(1.33-1.66), 1.34(1.17-1.53) respectively (all P value< 0.05).</p><p><b>CONCLUSION</b>Polymorphisms of rs2237897, rs2237892 and rs2237895 in the KCNQ1 gene were associated with occurrence of type 2 diabetes among Jiangsu province population.</p>


Asunto(s)
Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pueblo Asiatico , Genética , China , Epidemiología , Estudios de Cohortes , Estudios Transversales , Diabetes Mellitus Tipo 2 , Epidemiología , Genética , Genotipo , Canal de Potasio KCNQ1 , Genética , Polimorfismo de Nucleótido Simple
2.
Chinese Journal of Cancer ; (12): 281-286, 2012.
Artículo en Inglés | WPRIM | ID: wpr-295886

RESUMEN

Esophageal cancer is a common cancer worldwide and has a poor prognosis. The incidence of esophageal squamous cell cancer has been decreasing, whereas the incidence of esophageal adenocarcinoma has been increasing rapidly, particularly in Western men. Squamous cell cancer continues to be the major type of esophageal cancer in Asia, and the main risk factors include tobacco smoking, alcohol consumption, hot beverage drinking, and poor nutrition. In contrast, esophageal adenocarcinoma predominately affects the whites, and the risk factors include smoking, obesity, and gastroesophageal reflux disease. In addition, Asians and Caucasians may have different susceptibilities to esophageal cancer due to different heritage backgrounds. However, comparison studies between these two populations are limited and need to be addressed in the near future. Ethnic differences should be taken into account in preventive and clinical practices.


Asunto(s)
Humanos , Adenocarcinoma , Etnología , Genética , Consumo de Bebidas Alcohólicas , Asia , Epidemiología , Pueblo Asiatico , Genética , Carcinoma de Células Escamosas , Etnología , Genética , Neoplasias Esofágicas , Etnología , Genética , Población Blanca , Genética , Reflujo Gastroesofágico , Predisposición Genética a la Enfermedad , Incidencia , Obesidad , Polimorfismo de Nucleótido Simple , Factores de Riesgo , Fumar , Estados Unidos , Epidemiología
3.
Chinese Medical Journal ; (24): 481-485, 2012.
Artículo en Inglés | WPRIM | ID: wpr-262586

RESUMEN

<p><b>BACKGROUND</b>The key components of metabolic syndrome (MS) are waist circumference, blood pressure, fast blood glucose, high density lipoprotein cholesterol (HDL-c) and triglycerides (TG). These components have, separately and jointly, been associated with an increased risk of cardiovascular diseases. In this study, we aimed to explore the association between MS components and cancer risk in a population-based cohort in China.</p><p><b>METHODS</b>We established a population-based cohort with 17 779 individuals aged 35 and above at baseline in 2004 and 2005 in Changzhou, Jiangsu Province, China. All participants were face-to-face interviewed to complete a questionnaire and were accepted physical examinations including blood tests for glucose and lipids and physical measurements for obesity and blood pressure. In 2009, a total of 16 284 subjects (6886 men and 9398 women, 91.6%) attended the flow-up interviews and the participants or their family members reported all the hospitalizations and diseases including cancer occurred during the follow-up period. Multivariate Cox regression was used to estimate the hazard ratios (HRs) of metabolic syndrome components and cancer incidence.</p><p><b>RESULTS</b>There was a dose-response association between cancer risk and the number of MS components presented at baseline (P for trend = 0.012) and the HR (95% confidence interval (CI)) was 2.63 (1.27 - 5.45) for subjects carrying 3 or more metabolic syndrome components after adjustment for possible confounding factors. Specifically, the multivariate-adjusted HRs (95%CIs) for cancer risk in subjects with central obesity, high fasting glucose, low HDL-c were 1.94 (1.01 - 3.74), 2.04 (1.10 - 3.77) and 2.05 (1.09 - 3.88), respectively.</p><p><b>CONCLUSIONS</b>In this population-based, prospective cohort study in China, we found MS components, e.g., central obesity, high fasting glucose, low HDL-c were risk factors for cancer development. Early intervention of MS components may be also beneficial to reduce cancer burden.</p>


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pueblo Asiatico , Glucemia , Fisiología , China , Síndrome Metabólico , Epidemiología , Análisis Multivariante , Neoplasias , Epidemiología , Estudios Prospectivos , Triglicéridos , Sangre , Circunferencia de la Cintura , Fisiología
4.
Chinese Journal of Medical Genetics ; (6): 544-547, 2006.
Artículo en Inglés | WPRIM | ID: wpr-285081

RESUMEN

<p><b>OBJECTIVE</b>To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer.</p><p><b>METHODS</b>Using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population.</p><p><b>RESULTS</b>No significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR:1.16, 95% CI:0.88-1.54 for CDT1 GA+AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA+AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA+AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR:2.21, 95% CI:1.20-4.09).</p><p><b>CONCLUSION</b>These findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.</p>


Asunto(s)
Adulto , Femenino , Humanos , Persona de Mediana Edad , Pueblo Asiatico , Genética , Neoplasias de la Mama , Etnología , Genética , Estudios de Casos y Controles , Proteínas de Ciclo Celular , Genética , China , Geminina , Frecuencia de los Genes , Predisposición Genética a la Enfermedad , Genética , Genotipo , Reacción en Cadena de la Polimerasa , Polimorfismo Genético , Genética , Polimorfismo de Longitud del Fragmento de Restricción
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