Osteoblastic early attachment onto the surface of bioadhesive peptide modified pure titanium / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the long-term integrity and the biological function of interface between the bioadhesive peptide modified implant surface and peri-implant tissue.</p><p><b>METHODS</b>A short bioadhesive peptide containing Glycine-Tyrosine-Arginine-Glycine-Asparticacid-Serine (GYRGDS) sequence was immobilized onto the titanium implant surface by means of sol-gel coating technique and self-assembled monolayers (SAM). The chemical composition and organic functional groups on the titanium surfaces were characterized using XPS (X-ray photoelectron spectroscopy) and FTIR (Fourier transform infrared spectrometer). The adhesive strength and stability of osteoblasts on various implant surfaces were compared under flow condition.</p><p><b>RESULTS</b>The results showed that alkali/hot water aging treatment could apparently improve the content of -OH functional groups of titanium surface. The chemical reactive Ti-O-Ti bonding at the surface of titanium played a vital role in inducing the formation of organosilane SAM. GYRGDS peptide can be covalently grafted onto the surface of titanium by SAM technique. The resistance of freshly adherent osteoblasts to detachment by flow was shear time dependent. When the four groups were compared under the same flow stress condition (2.05 Pa) at three specific time spans (30 min, 1 h, 2 h), the cells retention rates in GYRGDS-grafted groups were 93.0%, 54.4%, 34.4% respectively and were much higher than those in non-coated groups.</p><p><b>CONCLUSIONS</b>It was suggested that GYRGDS might have positive effects on maintaining stability and adherence of cells onto the substrates under flow condition.</p>

Clinical application of maxillary sinus lift with Summers osteotome / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To introduce and evaluate the procedure and the effect of maxillary sinus lift with closed technique by Summers osteotome, bone grafting and simultaneous implant placement.</p><p><b>METHODS</b>66 cases with severely resorbed alveolar bone in maxillary posterior region received sinus lift with Summers osteotome, simultaneously bone grafting and implants placement. The final restoration was finished at 6 months postoperatively.</p><p><b>RESULTS</b>The operation procedure were eventless in the 66 cases, the sinus floor were elevated by 2-5 mm, three-dimensional reconstruction of the CT scan pictures showed the smooth dome profile of the lifting sites and no signs of laceration on the membrane, and there were no maxillary antritis after operation. After 6 months, no significantly bone graft resorption and good osseointegration were noticed in X-ray imaging. The final restoration was finished at this time. 12-24 months after the restoration, all implants inserted were remain, the hard and soft tissue were healthy, prosthesis were stable and functioned. X-ray showed good osseointegration in the lifting sites, the vertical resorption around the implants were less than 1 mm.</p><p><b>CONCLUSION</b>With properly use of Summers osteotome, scraps of the bone in the implant sockets can be pushed into the sinus, these autogenous bone scraps were in favor of the osseogenesis and the sinus floor can be easily elevated by the method with very infrequent complications. It enlarged indication of dental implants and avoided operation of harvesting autogenous bone in other site. The method is simple and valuable to clinical application.</p>

Clinical study of autotransplanting of impacted anterior tooth and premolar / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the effect of autotransplantation of impacted anterior tooth and premolar.</p><p><b>METHODS</b>Nineteen teeth of 19 patients were made autotransplantation. Fifteen impacted anterior teeth were transplanted to their normal positions. Four premolars were transplanted into missing anterior spaces. Four weeks after surgical procedure, root canal therapy was underwent. Clinical and radiographic examintation of 19 transplanted teeth were carried out after 18-months to 5-years.</p><p><b>RESULTS</b>Nineteen teeth were stable with no sign of inflammatory resorption or periapical lesion.</p><p><b>CONCLUSION</b>Autotransplantation may be a better treatment method to impacted tooth and missing anterior when they can't be treated by orthodontic method.</p>

Clinical application of maxillary sinus augmentation, bone graft and simultaneously placement of implant with trephine bur / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To introduce and evaluate the procedure and the effect of localized management of sinus floor (LMSF), bone graft and simultaneous implant placement with trephine bur in maxillary posterior region.</p><p><b>METHODS</b>24 patients without enough alveolar bone height received LMSF, bone grafting and implants placement were carried out simultaneously.The autogenous bone were harvested by trephine bur in situ. Patients were followed up after 1 week, 1, 3 and 6 month.</p><p><b>RESULTS</b>There was no implant loose or lost and maxillary antritis. 6 months postoperatively, bone graft reformed to new bone seen in X-ray films, sinus floors were augmented and reached the requirements of dental implants. The implant osseointegrated tightly with new bone which was satisfactory to second-step prosthesis after implant placement of 6 months later.</p><p><b>CONCLUSIONS</b>The method enlarges the indication of dental implants and avoids operation of harvesting autogenous bone in other site. It is simple and valuable to clinical application.</p>