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Genomics & Informatics ; : 200-210, 2013.
Artículo en Inglés | WPRIM | ID: wpr-11254

RESUMEN

Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.


Asunto(s)
Biología , Conjunto de Datos , Redes Reguladoras de Genes , Estudio de Asociación del Genoma Completo , Tamizaje Masivo , Análisis de Secuencia por Matrices de Oligonucleótidos
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