RESUMEN
Objective To investigate the clinical data of patients with hepatocellular carcinoma in Ningxia Hui Autonomous Region through questionnaire survey,explore the association between the risk factors of liver cancer and the onset age of disease in this area and provide evidence for prevention and treatment of liver diseases.Methods A retrospectively analysis was conducted in 250 patients with primary hepatocellular carcinoma by using their clinical data collected through questionnaire survey to understand the relationship between gender,smoking,alcohol use,hypertension,diabetes mellitus,hyperlipidemia,family history of liver cancer,liver cirrhosis,HBV infection,eating fish history and other factors and the incidence of hepatocellular carcinoma by univariate and logistic multivariate regression models.Results Univariate regression analysis showed that hypertension,diabetes mellitus,hyperlipidemia and family history of liver cancer,HBV infection,cirrhosis,smoking,eating fish history were risk factors for the early onset of liver cancer,t=4.150,P＜0.05;t=3.752,P＜0.05;t=5.676,P＜0.05;t=9.731,P＜0.05;t=15.824,P＜0.001;t=5.724,P＜0.05;t=11.662,P＜0.01;t=4.472,P＜0.05,respectively,but logistic multivariate regression model analysis indicated that smoking,HBV infection were independent risk factors,OR=3.211(95％CI:1.134-4.642),OR =7.31 (95％CI:4.312-21.072).Conclusions The risk factors affecting the age of liver cancer onset vary with area diet pattern alcohol use did not influenced the age of liver cancer onset,but smoking and HBV infection were the independent risk factors for early onset of liver cancer.It is necessary to strengthen the HBV infection prevention and control and advise people to quit smoking.
RESUMEN
Objective To investigate the clinical data of patients with hepatocellular carcinoma in Ningxia Hui Autonomous Region through questionnaire survey,explore the association between the risk factors of liver cancer and the onset age of disease in this area and provide evidence for prevention and treatment of liver diseases.Methods A retrospectively analysis was conducted in 250 patients with primary hepatocellular carcinoma by using their clinical data collected through questionnaire survey to understand the relationship between gender,smoking,alcohol use,hypertension,diabetes mellitus,hyperlipidemia,family history of liver cancer,liver cirrhosis,HBV infection,eating fish history and other factors and the incidence of hepatocellular carcinoma by univariate and logistic multivariate regression models.Results Univariate regression analysis showed that hypertension,diabetes mellitus,hyperlipidemia and family history of liver cancer,HBV infection,cirrhosis,smoking,eating fish history were risk factors for the early onset of liver cancer,t=4.150,P＜0.05;t=3.752,P＜0.05;t=5.676,P＜0.05;t=9.731,P＜0.05;t=15.824,P＜0.001;t=5.724,P＜0.05;t=11.662,P＜0.01;t=4.472,P＜0.05,respectively,but logistic multivariate regression model analysis indicated that smoking,HBV infection were independent risk factors,OR=3.211(95％CI:1.134-4.642),OR =7.31 (95％CI:4.312-21.072).Conclusions The risk factors affecting the age of liver cancer onset vary with area diet pattern alcohol use did not influenced the age of liver cancer onset,but smoking and HBV infection were the independent risk factors for early onset of liver cancer.It is necessary to strengthen the HBV infection prevention and control and advise people to quit smoking.
RESUMEN
Objective To investigate the clinical and pathological features of elderly patients with hepatocellular carcinoma (HCC)and the prognosis after radical resection.Methods From January 2013 to December 2014,98 elderly patients with primary liver cancer were enrolled in this study,with 120 non-elderly patients with primary liver cancer serving as the control group.Comparison was made concerning clinical and pathological characteristics,short term postoperative outcomes and long-term prognosis between the two groups.Results The average age of patients in the elderly group(68.4±3.7)was significantly higher than in the control group(53.6 ±5.3),and the difference was statistically significant(t=23.376,P＜0.001).The positive rate of HBsAg in the elderly group was 38.8 ％,higher than in the control group (70.0 ％),and the difference was statistically significant (x2 =21.341,P＜0.001).The incidence of liver failure in the elderly group was 4.1％,higher than in the control group (0.0 ％),and the difference was statistically significant (xe =4.990,P =0.026).There was no significant difference in survival rate at 6 months,1 year and 2 years between two groups (x2 1.427,2.127,and 0.510,each P＞0.05).There was no significant difference in recurrence rate between the two groups at 1 year and 2 years(x2 =0.205 and 0.706,each P＞0.05).Conclusions Elderly patients with hepatocellular carcinoma present favorable clinical and pathological features and show similar short and long-term outcomes,compared with non-elderly patients.Radical resection is valuable in the treatment of hepatocellular carcinoma in elderly patients.