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Objective To explore the antitumor mechanism of xianhe yanling recipe( XHYLR ). Methods The mechanism of action of 241 compounds contained in the Chinese medicine, XHYLR was studied by using computational pharmacological. Methods including molecular docking,biotechnology network,chemical space technology and the prediction of absorption,distribution,metabolism,excretion and toxicity( ADME/T). Results Most of the compounds in XHYLR had good drug-like properties. Distribution of 241 compounds in chemical space also revealed that these compounds showed similar anti-tumor activity. It suggested that the prescription of XHYLR was reasonable. The phenomena that one molecular interacted with multiple target proteins and several molecules interact with one target protein were observed in XHYLR. For example,the COX-2 interacted with 40 micromolecules,and catechin interacted with five targets including COX-2. Conclusion These results are helpful for understanding the complicated mechanism of anti-tumor activity of XHYLR.
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Objective To investigate the efficacy of efficacy of warm needling plus Yunnan Baiyao aerosol in treating ankylosing spondylitis. Method Ninety patients with ankylosing spondylitis were randomly allocated to three groups, 30 cases each. The treatment group received warm needling plus Yunnan Baiyao aerosol in addition to medication;control group 1, warm needling plus Yunnan Baiyao tincture in addition to medication; control group 2, routine medication for rheumatism. Result There was no statistically significant difference between the treatment group and control group 1 (P>0.05) and there was between the treatment group and control group 2 (P＜0.05), indicating that the therapeutic effect was better in the treatment group than in the control group. Conclusion Warm needling plus Yunnan Baiyao aerosol can effectively relieve the pain, improve joint function and activity, prevent joint stiffness and deformity and reduce the disability rate in ankylosing spondylitis patients.