RESUMEN
Objective To observe the curative effect of Huoxue-Tongluo-Zhitong ointment treating soft tissue injury,and the safety of application on skin.Methods The treatment group was treated with Huoxue-Tongluo-Zhitong ointment,while the comparison group was treated with Votalin Pill.Acute toxicity experiment,irritant experiment and hypersensitivity experiment of skin were performed on New Zealand white rabbits.Results Huoxue-Tongluo-Zhitong ointment decreased local edema and leukocyte effusion,accelerate the re-absorption of hematomas.On injury signs index,group A [ (0.32± 0.35),(0.29± 0.27) ] was better than group B [ (0.58±0.42),(0.91 ±0.34) ] (P＜0.05).The pathological process in group A and B was obviously reduced than group C (P＜0.05).In the neutruphil infiltration density measuring:compared with group C,group A and B both showed significant difference (P＜0.05),but there was no significant difference between group A and B (P＞0.05).Conclusion Huoxue-Tongluo-Zhitong ointment performed well on the treatment of soft issue injury,with no toxicity,irritation,and hypersensitivity of skin,as well as high safety of administration.