RESUMEN
Abstract The objective of this study was to determine the prevalence and describe the factors associated with off-label drug use in an adult intensive care unit (ICU) of a Brazilian hospital. An analytical, cross-sectional, prospective study was conducted in the adult ICU population from March 2018 to May 2018. Off-label use of medication was classified by indication, dosage, route of administration, type and volume of diluent, and duration of administration. Most patients were female (57.89%), non-elderly (56.14%), and had a mean age of 54.44 ± 17.15 years. The prevalence of off-label drug use was 70.31%, but was not associated with the clinical severity of the patients. A statistically significant association was observed between label use of drugs and prescribing potentially inappropriate medicines (PIM). The most common reasons for off-label drug use were therapeutic indication (19.58%) and volume of diluent (23.30%). Drug administration by enteral tubes accounted for the largest number of off-label uses due to route of administration (90.85%). There was a higher prevalence of off-label use of systemic antimicrobials (14.44%) and norepinephrine (9.28%). Our study provided a broad characterization of off-label drug use in an adult ICU and showed why it is important for health professionals to evaluate the specific risks and benefits of this practice
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Brasil/etnología , Preparaciones Farmacéuticas/provisión & distribución , Uso Fuera de lo Indicado/estadística & datos numéricos , Hospitales/clasificación , Unidades de Cuidados Intensivos/clasificación , Organización y Administración/estadística & datos numéricos , Prevalencia , Cuidados Críticos/estadística & datos numéricosRESUMEN
Ácido Centipédico (AC), um diterpeno isolado Egletes viscosa Less. (Asteraceae) foi avaliado em modelos experimentais de lesão gástrica aguda e crônica, e, em modelo de lesão intestinal. AC (50 e 100 mg/kg, v.o.) atenuou significativamente as lesões gástricas induzidas por etanol (53 e 79% de inibição). Na dose de 50 mg/kg mostrou envolvimento do óxido nítrico, prostaglandinas, canais de potássio ATP-dependente, mas de receptores TRPV1. O diterpeno diminuiu significativamente a depleção dos grupos sulfidrilas não-proteicos e SOD e diminuiu a formação de MDA, associados à administração de etanol. AC aumentou ainda os níveis de muco gástrico. No modelo de etanol acidificado AC (50 e 100 mg/kg, v.o.) e lansoprazol (30 mg/kg, v.o.) atenuaram significativamente as lesões gástricas...