Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Tipo de estudio
Intervalo de año
1.
Braz. j. microbiol ; 49(2): 407-413, Apr.-June 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-889247

RESUMEN

Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the activity of antifungal drugs. Our results suggest that Cou-UMB16 inhibits Aspergillus spp. virulence factors (mycelia growth and germination of conidia) and affects the structure of the fungal cell wall. When applying Cou-UMB16 in combination with azoles, both synergistic and additive effects were observed. This study concludes that Cou-UMB16 inhibits mycelial growth and spore germination, and that the activity is due to its action on the fungal cell wall, and that Cou-UMB16 could act as an antifungal modifier.


Asunto(s)
Antifúngicos/aislamiento & purificación , Antifúngicos/farmacología , Aspergillus/efectos de los fármacos , Cumarinas/aislamiento & purificación , Cumarinas/farmacología , Sinergismo Farmacológico , Aspergillus/crecimiento & desarrollo , Azoles/farmacología , Membrana Celular/efectos de los fármacos , Pared Celular/efectos de los fármacos , Hifa/efectos de los fármacos , Hifa/crecimiento & desarrollo , Esporas Fúngicas/efectos de los fármacos , Esporas Fúngicas/crecimiento & desarrollo
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA