The Clinic Effect of 2-Hour Feeding in Premature Infants with Very Low Birth Weight / 昆明医科大学学报

Objective To study the effect and application of 2-hour feeding in premature infants with very low birth weight.Methods 162 newborn cases with very low birth weight in the pediatrics department, The Third People's Hospital of Yunnan Province in September 2016-September 2017, were randomly divided into two groups:the experimental group with 81 cases (feeding every 2 hours), and the control group with 81 cases (feeding every three hours). The application effect was compared in the two groups.Results Comparing the gastrointestinal tract feeding tolerance, growth rate, feeding time, days of intravenous infusion of high nutrient solution, risk of intrahepatic cholestasis disease, and days of hospitalization between the experimental group and the control group, the data had significant differences (P ＜ 0.05). Conclusion 2-hour feeding in low birth premature infants can effectively stimulate the intestinal peristalsis, improve children's tolerance, speed up the growth rate, resume the gastrointestinal tract feeding as soon as possible, reduce the risk of cholestasis occurs and reduce the number of days in hospital. In clinical work, children's feeding tolerance, gastric retention, and bloating situation should be under strict observation and be delt with in time. These methods are worth promoting in the neonatal wards.

Placental Foxp3 expression in patients with preeclampsia and correlation of Foxp3 gene locus 924 (rs2232365) polymorphism with preeclampsia / 南方医科大学学报

<p><b>OBJECTIVE</b>To detect changes of Foxp3 expression in the decidua in patients with preeclampsia and investigate the correlation of Foxp3-924 (rs2232365) polymorphisms with preeclampsia.</p><p><b>METHODS</b>From October 2011 to December 2012, 252 normal pregnant women and 156 preeclampsia patients of Han nationality from the same geographic region were tested for Foxp3-924 genotypes by polymerase chain reaction with sequence-specific primer (PCR-SSP). Sixty-eight of the patients with preeclampsia (33 with mild and 35 with severe preeclampsia) and 30 of the normal pregnant women were also examined for Foxp3 expression in the decidua using immunohistochemical method.</p><p><b>RESULTS</b>Foxp3 positive expression rates in the decidua was 51.52% in mild preeclampsia and 28.57% in severe preeclampsia cases, significantly lower than that in the control group (86.67%, P<0.05). In preeclampsia patients, the frequencies of Foxp3-924G/G, G/A, and A/A genotypes were 0.1346, 0.4615 and 0.4038, respectively, and the frequencies of Foxp3-924A and Foxp3-924 G were 0.6346 and 0.3654, respectively. The genotype frequencies of Foxp3-924G/G, G/A and A/A in the control group were 0.1508, 0.4087 and 0.4405, respectively, and the frequencies of Foxp3-924 A and Foxp3-924 G were 0.6448 and 0.3552, respectively. No significant differences were found in the gene frequencies of Foxp3-924G/A between preeclampsia patients and the control group (P>0.05).</p><p><b>CONCLUSION</b>The expression level of Foxp3 in the placental tissue of preeclampsia patients is significantly lower than that in normal pregnant women, suggesting that lowered Foxp3 expression decreases the immunosuppressive function and causes imbalance of immune tolerance between maternal-fetal to induce preeclampsia. Foxp3-924 polymorphisms is not significantly correlated with the occurrence of preeclampsia.</p>

Study on the reliability and validity of the 66-item version on the gross motor function measure in 0-3 year olds with cerebral palsy / 中华流行病学杂志

<p><b>OBJECTIVE</b>To examine the reliability and validity of the 66-item version on the gross motor function measure (GMFM-66) to assess the gross motor functions of children below 3 years oldwith cerebral palsy.</p><p><b>METHODS</b>298 valid samples were obtained from 171 children with cerebral palsy (male 126, female 45 with mean age 19 months, age range 3-36 months) measured with GMFM-88. Then a 73-item version of GMFM (GMFM-73) special for these children was obtained by Rasch analysis. Both GMFM-66 and GMFM-73 scores of to each sample were obtained. The reliability and validity of GMFM-66 were evaluated through analyzing the correlation between the scores and between the changed scores of these two GMFM versions. The relative precision of GMFM-73 versus GMFM-66 was also analyzed.</p><p><b>RESULTS</b>Significant correlations were found between the scores and between the changed scores of these two versions of GMFM. A 14% less gain in relative precision was achieved when using GMFM-73 versus GMFM-66.</p><p><b>CONCLUSION</b>Results indicated that the GMFM-66 had good reliability and validity in assessing the gross motor functions of children below 3 years old with cerebral palsy.</p>

Applications of Gross Motor Function Measure Scale and Peabody Developmental Measure Scale-Gross Motor in the evaluation of children with cerebral palsy / 中国康复理论与实践

@#Objective To compare the advantages of two gross motor measure scales, Peabody Developmental Measure Scale Gross Motor (PDMS-GM) and Gross Motor Function Measure Scale (GMFM), in the evaluation of children with cerebral palsy (CP).Methods The gross motor functions of 29 CP children, 0-3 years old, were evaluated three times using PDMS-GM and GMFM respectively. The improvement percentile each month of PDMS-GM and GMFM were compared by t test.Results There was significant difference between the improvement percentile each month of PDMS-GM and GMFM. Conclusion The GMFM was more sensitive than PDMS-GM in the evaluation of CP children especially in the evaluation of treatment effect.