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Objective To investigate the dynamic change and the clinical curative effect evaluation of plasma (1-3)-beta glucan D (BG) in the patients with pulmonary disease complicating fungal infection .Methods The MB-80 miroorganism dynamic rapid de-tection system and fungi BG detection kits were adopted to detect plasma BG content before and after treatment in 87 cases of pul-monary disease complicating fungal infection and the controls .The sputum culture in the patients was performed before and after treatment .Results Plasma BG levels before antifungal therapy ,at 1 ,2 weeks after treatment in 87 patients were (162 .81 ± 70 .03) , (15 .89 ± 30 .88) and (4 .58 ± 7 .87)pg/mL ,which in the control group was (5 .62 ± 1 .83)pg/mL ,plasma BG level had statistical differences between before treatment and at 1 ,2 weeks after treatment in the patients with the control group (P<0 .05);Plasma BG levels between at 1 week after treatment with at 2 weeks after treatment and the control group had statistically significant differ-ences (P<0 .05) .Among 87 patients ,66 cases were positive sputum culture at 1 week after antifungal drug treatment and 9 cases were positive sputum culture at 2 weeks after treatment .Conclusion Continuously monitoring the patient′s plasma BG level com-bined with the sputum fungal culture results ,clinical symptoms and lung shadow in X-ray has certain clinical value to judge the anti-fungal effect .
RESUMEN
Objective To investigate the changes of serum high-sensitivity C-reactive protein (hs-CRP) in cerebral infarction patients and its relationship with the condition of cerebral infarction and prognosis.Methods Ninety-seven cases with cerebral infarction patients (observation group) and 72healthy subjects (control group) were selected.The levels of hs-CRP at different periods were detected by enzyme-linked immunosorbent assay (ELISA) in observation group, and its relationship with the severity of cerebral infarction level degree and neurological deficit scores was analyzed and compared with control group.Results The levels of hs-CRP at the 24th day[(3.9 ± 1.8) mg/L]were lower than those at the 1,4,8th day [(5.8 ± 1.9), (6.4 ± 2.4), (5.7 ± 2.0) mg/L]in observation group, and the difference was significant (P＜ 0.05 ).The levels of hs-CRP showed positive correlation with neurological deficit scores (r = 0.214, P ＜ 0.01 ).Conclusions The levels of hs-CRP have close relationship with cerebral infarction, and it can be used as an important biological indicator in evaluating the severity and prognosis of cerebral infarction and has clinical value in prediction and intervention of cerebral infarction.