Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery, radiotherapy, chemotherapy, immunotherapy, and endocrine therapy are currently the main treatments for this cancer type. However, some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy, resulting in limited treatment efficacy. Consequently, traditional Chinese medicinal materials (TCMMs) as natural products have become an attractive source of novel drugs. In this review, we summarized the current knowledge on the active components of animal-derived TCMMs, including Ophiocordycepssinensis-derived cordycepin, the aqueous and ethanolic extracts of O.sinensis, norcantharidin (NCTD), Chansu, bee venom, deer antlers, Ostreagigas, and scorpion venom, with reference to marked anti-breast cancer effects due to regulating cell cycle arrest, proliferation, apoptosis, metastasis, and drug resistance. In future studies, the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies. Furthermore, large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.

Personality traits on higher vocational students with mathematics learning difficulties / 中华行为医学与脑科学杂志

ObjectiveTo explore the personality traits on higher vocational students with mathematics learning difficulties(MD).MethodsAll students of three grades in their first year were divided into MD students ( n =486) and outstanding students ( n =407 ) according to their final math scores.Cattell's 16 PF Questionnaires was used to assess the personality.ResultsStudents with MD got significantly higher records in personality factors of aggressiveness (6.59 ± 1.94 ),excitability ( 7.29 ± 2.24 ),sensitivity ( 5.85 ± 1.98 ),suspicion ( 3.51 ±2.03 ),fantasy(5.76 ± 1.86 ),urbane ( 5.81 ± 1.75 ),tense ( 5.63 ± 2.05 ),adapting and anxiety type ( 4.49 ±2.23 ),introverted and expert-oriented type(7.59 ± 2.43 ),and cowardice and decisive type ( 5.04 ± 1.62 ) than outstanding students(P＜0.05) ;however,they got lower records in personality factors of steadiness(5.89 ±2.19),perseverance (4.41 ± 1.98 ),independence ( 3.74 ± 1.77 ),emotional with unruffled alert type ( 5.51 ± 1.81 ),professional achievements (52.72 ± 10.66),growth ability in new environments ( 18.78 ± 3.91 ) (P ＜ 0.05 ).ConclusionHigher vocational students with MD have sensitive,suspicious,nervous,anxious,exoscopic,excited,fantasy personalities,lacking self-control,elasticity,carefulness and constancy.

Development of vocational interest scale of university students / 中华行为医学与脑科学杂志

Objective To develop a Vocational Interest Scale of University Students which fits the contemporary current university students, and it could give directions to university students when they were choosing a vocation. Methods Taking Holland's theory as the guide and taking 65 items of Self-Directed Search (SDS) for reference, then adding 28 items which standed for contemporary current university students' ideas of vocational interest to develop original Vocational Interest Scale of University Students. Results The formal scale included 7 tendency(subscales) and 61 items,7 subscales were technology tendency, administration tendency, business trade tendency ,art tendency ,investigation tendency,transaction tendency. The reliability of the scale was very good, the Cronbach's coefficients and spit-half reliability were over 0.7. The factor analysis abstracted 7 factors and the total variance explained reached 45%. The factor analysis results indicated that the scale had a good structure.Conclusion This scale make vocational interest as measuring object and could be a useful tool to give directions to university students who are choosing some vocation.

Preliminary development of scale on work values for college students / 中华行为医学与脑科学杂志

Objective To develop the scale on work values for college students. Methods 63 items were determined through reviewing items in related literatures and scales, experts consulting and panel discussion.528 students from 3 universities in Shanghai were enrolled in the study. The data were analyzed through exploratory factor analysis,discrimination analysis,reliability analysis and other statistical analysis methods. Results College students' work values comprises six dimensions: self-value dimension ( including two sub-dimensions: self-esteem dimension and self-realization dimension), social-value dimension, dimension of the working environment, wages and welfare dimension , job stability dimension, and the dimension of social status. 43 items were reserved after exploratory factor analyses. The coefficient of reliability of the 43 items was 0.943, and the item loading of the 43 items was 0. 321 ～ 0. 792. Conclusion The discernment, internal consistency and validity of the scale accord with psychometric demands.