Optimal cultivation conditions of marine fungi KLEB-07 / 中国海洋药物

It was found that the metabolites produced by a marine fungi KLEB-07 showed the induction of cell apoptosis activity on mouse tsFT210 cells.In order to find the best fermentation condition,the optimization of fermentation medium was studied.Activities of the ferments of KLEB-07 under different fermentation media and conditions,and the stability of the ferments were investigated.The results showed that the KLEB-07 produced the highest antitumor bioactivity of the ferments under the conditions of 28℃ and 130 r?min~(-1) for 7 days.The bioactive substances of ferments were stable and mainly existed in ethyl acetate layer.These results provide valuable informations for the further study of the antitumor active substances of KLEB-07.