RESUMEN
A soluble antigen complex (SAC) derived from the ruptured promastigotes of Leishmania donovani parasites (LD-SAC) was used for complement fixation test (CFT) in leprosy Cases of tuberculoid and borderline tuberculoid leprosy, post-kala azar dermal leishmaniasis (TT, BT, PKDL) and control sera gave negative CFT. Smear-positive cases of borderline (BB, BL) and lepromatous (LL) leprosy and drug-resisting cases of pulmonary tuberculosis gave positive CFT; smear-negative cases of LL leprosy sera also gave positive CFT. Sera of smear-negative inactive LL patients contained only PGL-1 and PDIM antigens for a long time after they become inactive. Therefore, the positive CFT in inactive LL makes us suspect whether PGL-1 is present in LD promastigotes.
Asunto(s)
Adulto , Animales , Antígenos Bacterianos/inmunología , Antígenos de Protozoos/análisis , Pruebas de Fijación del Complemento , Reacciones Cruzadas , Glucolípidos/análisis , Humanos , Leishmania donovani/crecimiento & desarrollo , Leishmaniasis Visceral/inmunología , Lepra/diagnóstico , Lepra Dimorfa/diagnóstico , Lepra Lepromatosa/diagnóstico , Lepra Tuberculoide/diagnóstico , Masculino , Persona de Mediana Edad , Mycobacterium leprae/inmunología , Tuberculosis Resistente a Múltiples Medicamentos/diagnósticoRESUMEN
Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.