RESUMEN
Hypereosinophilic syndrome is a rare disease with variable outcome. It is usually a disease of young adults. Involvement of the heart and or lungs occurs in 40-60% of cases which can lead to severe heart and lung failure. Direct tissue eosinophilic infiltration and release of their toxic granules are the main underlying pathology. In this study, we report a young lady presented with a short history of fever, easy fatigability, weight loss and bilateral lung infiltrates. The diagnosis was consistent with Hypereosinophilic syndrome and despite treatment with pulses of intravenous Methylprednisolone, oral Prednisolone, Hydroxyurea and Imitinab Mesylate, the patient unfortunately died because of severe respiratory failure. The age group, striking eosinophilia and fulminant fatal course without neoplasia warranted reporting