RESUMEN
Otosclerosis is a collagen disorder of otic capsule, the cause of which is still unknown. In the present work histological studies of Skin biopsies from patients with otosclerosis were carried out Twenty five patients with otosclerosis and five age and sex matched control were included. Two skin biopsies were taken from two different regions. Sections were prepared and stained with haematoxylin and eosin and with verhoeff and Van Gieson's stains. Histological examination of the skin patients, compared with the control showed thinner epidermis in 40% decreased thickness and density of the collagen fibers and bundles as well as decreased or absent elastic fibers the collagen was seen in fine either diffusely arranged or loosely textured or in thin bundles loosely textured. These results may suggest otosclerosis is caused by a generalized connective tissue disorder