RESUMEN
Introduction: Acetaminophen is the most commonly used drug for temperature reduction in febrile children, which is used orally or rectally. The effectiveness of rectal versus oral Acetaminophen is not well established
Objective: This study is designed to compare the antipyretic effectiveness of rectal acetaminophen dose 15mg/kg to the standard oral dose of 15mg/kg
Materials and Methods: A randomized clinical trial was performed on 60 patients aged 6 months to 6 years with fever>/=39 rectally. The patients were randomly assigned in one of two groups. First 39[degree]c group received 15mg/kg Acetaminophen rectally and the second group received same dose orally and their body temperature was measured one and three hours after Acetaminophen administration
Results: The mean temperature reduction, 60 and 180 minutes after use of acetaminophen were 1.07 +/- 0.16 and 1.74 +/- 0.25
Conclusion: Effectiveness of oral and rectal Acetaminophen with 15mg/kg dose is similar in decreasing children's fever. Standard [15mg/kg] oral and [15mg/kg] rectal acetaminophen has similar antipyretic effectiveness