RESUMEN
Background: Inhibition of angiogenesis is one of the goals of cancer treatment. In traditional medicine, Allium sativum L. and Ferula assa-foetida are consider as the important medicinal plants. The effect of electromagnetic field [EMF] on different aspects of cell growth has been confirmed
Objective: The aim of this study was to investigate the effect of shoots of Allium sativum L., Ferula assa-foetida extract and low frequency EMF on angiogenesis
Methods: 100 fertilized eggs were randomly divided into 10 groups: control [treated with distilled water], sham one [normal saline], sham two [EMF off], experimental one [shoot of Allium sativum L. extract], experimental two [shoot of Ferula assa-foetida], experimental three [combination of Allium sativum L. and Ferula assa-foetida], experimental four [EMF with intensity of 100 gauss], experimental five [Allium sativum L. + EMF], experimental six [Ferula assafoetida + EMF], experimental seven [combination of Allium sativum L. and Ferula assa-foetida + EMF]. Extract was injected on the 8th day of incubation and samples were exposed to EMF on 10th day. On 12th day, Chorioalantoic membrane was photographed and the length and numbers of vessels were measured
Results: There was a significant decrease in mean number and length of vessels in experimental groups one, two, four, five and six compared with the control group. The most significant decrease was created in group three, especially in group seven [P<0.05]. In addition, extract of Ferula assa-foetida has anti-angiogenesis effect more than Allium sativum L
Conclusion: Allium sativum L. and Ferula assa-foetida have inhibitory effects on angiogenesis and these effects amplifying by EMF
RESUMEN
The effects of feeding diets containing Salbutamol [0, 1, 3, 5 and 7 mg/kg diet] from 21 to 49 days of age on growth performance and carcass characteristics in 180 male and 180 female Japanese quails [Coturnix japonica] were studied using a factorial arrangement based on completely randomized design. Gender had significant effect on weight gain [P<0.05]. Salbutamol in the diets increased weight gains but the differences were not statistically significant [P>0.05]
Salbutamol increased [P<0.05] weight gains in both sexes, but the magnitude of increasing was greater in females. Weight gain in males and females receiving the diet containing 7 mg Salbutamol/kg increased by 13 and 10 g, respectively compared to the control groups. Food intake was affected by Salbutamol and was higher [P<0.01] in female than male quails. Diets containing Salbutamol increased food intake in male and decreased in female quails [P<0.01] compared with the control groups. Food intake was lowest in females fed 7 mg Salbutamol/kg diet. The food conversion ratio [FCR] was lower [better] [P<0.05] in females than in males. FCR were improved [P>0.05] by Salbutamol administration. Gender affected leg weight [P<0.05], breast weight, relative weight of leg and liver weight [P<0.01]
The breast weight, leg weight and liver weight were significantly higher in females than males but relative weight of leg was significantly lower [P<0.01] in females. The breast weight, relative weight of breast and relative weight of leg were significantly affected by Salbutamol. Gender, Salbutamol and their interactions did not affect the chemical composition of breast muscle
The results of the experiment demonstrated that, Salbutamol had beneficial effects on growth performance and carcass characteristics and it seems that feeding 7 mg Salbutamol/kg diet was more effective in female than male Japanese quails?