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1.
Immune Network ; : e46-2018.
Artículo en Inglés | WPRIM | ID: wpr-718579

RESUMEN

Dectin-1 is a major receptor that recognizes fungal cell wall β-glucan. We previously reported that heat-killed Saccharomyces cerevisiae (HKSC), a Dectin-1 agonist, selectively induces IgG1 class switching in mouse B cells. Dectin-1 is also expressed on human B cells; however, Dectin-1 function in human B cells remains unknown. This study aimed to investigate the direct effect of in vitro stimulation using HKSC on Ig class switching in human B cells. HKSC selectively induced the expression of germline γ4 transcripts (GLTγ4) by human B cell line 2E2, and HKSC significantly augmented GLTγ4 promoter activity. Moreover, HKSC selectively enhanced GLTγ4 expression and IgG4 production by anti-CD40-activated human tonsillar resting B cells. Thus, these results suggest that Dectin-1 maybe involved in selective IgG4 class switching by human B cells.


Asunto(s)
Animales , Humanos , Ratones , Linfocitos B , Línea Celular , Pared Celular , Cambio de Clase de Inmunoglobulina , Inmunoglobulina G , Técnicas In Vitro , Saccharomyces cerevisiae , Saccharomyces
2.
Immune Network ; : 331-336, 2015.
Artículo en Inglés | WPRIM | ID: wpr-92646

RESUMEN

Ginsenosides are the major components of ginseng, which is known to modulate blood pressure, metabolism, and immune function, and has been used to treat various diseases. It has been reported that ginseng and several ginsenosides have immunoregulatory effects on the innate and T cell-mediated immune response. However, their effects on the humoral immune response have not been fully explored. The present study examined the direct effects of red ginseng extract (RGE) and ginsenosides on mouse B cell proliferation and on antibody production and the expression of germline transcripts (GLT) by mouse B cells in vitro. RGE slightly reduced B cell proliferation, but increased IgA production by LPS-stimulated B cells. Furthermore, ginsenoside Rg1 and 20(S)-Rg3 selectively induced IgA production and expression of GLTalpha transcripts by LPS-stimulated B cells. Collectively, these results suggest that ginsenoside Rg1 and 20(S)-Rg3 can drive the differentiation of B cells into IgA-producing cells through the selective induction of GLTalpha expression.


Asunto(s)
Animales , Ratones , Formación de Anticuerpos , Linfocitos B , Presión Sanguínea , Proliferación Celular , Ginsenósidos , Inmunidad Humoral , Inmunoglobulina A , Metabolismo , Panax
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