Pantoea agglomerans bloodstream infection in preterm neonates

To report an uncommon incidence of sporadic bloodstream infection [BSI] caused by Pantoea agglomerans in preterm neonates. Case Presentation and Intervention: Fives cases of nosocomial BSI with P. agglomerans in preterm neonates [weight 1,500 g; age 8-17 days; gestational age 26-30 weeks] are presented. All cases were late onset neonatal sepsis [> 7 days of age]. Lethargy, skin mottling and bradycardia were often present. Although there was no evidence of pneumonia, desaturation was a common feature. Thrombocytopenia developed in 4 patients, metabolic acidosis in 2 and jaundice in 2. No bleeding tendency or disseminating intravascular coagulation was recorded. Organisms cultured from blood were identified by the Vitek-2 system [bioMerieux, France] and the findings confirmed by testing the isolate on the API 20E system. All isolates shared in vitro susceptibility to gentamicin, amikacin, ciprofloxacin, piperacillin/tazobactam and meropenem. One patient was treated with a cefotaxime/amikacin combination, 2 with meropenem and the remaining 2 with tazocin. All patients responded well to antibiotic treatment and survived. P. agglomerans is an unusual pathogen in the etiology of neonatal sepsis. Despite significant clinical deterioration, early detection and proper antibiotic therapy carry a favorable outcome

Ochrobactrum anthropi bacteremia in a child with inborn error of mitochondrial fatty acid oxidation

To report an incident of bacteremia caused by Ochrobactrum anthropi. The case of a female child aged 2 years and 10 months with a known history of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency who developed O. anthropi bacteremia during hospital stay is presented. Patient's history, clinical findings, laboratory and radiological investigations were thoroughly reviewed. The cultured organism was identified using Micro Scan Walk Away 96 SI [Dade Behring] as well as by conventional techniques. Imipenem resistance was confirmed by the conventional Kirby-Bauer disk diffusion technique on Muller-Hinton agar with no zone of inhibition around a 10-microg imipenem disk [Hi Media] using the 0.5 McFarland standard. This report shows O. anthropi as a rare nosocomial pathogen that affected a patient who was immunocompromised. The O. anthropi showed multidrug resistance