RESUMEN
PURPOSE: The therapeutic effects of imipramine and DDAVP in primary monosymptomatic enuretic children were compared using a randomized, prospective study. MATERIALS AND METHODS: The study subjects consisted of 23 children, with a mean age of 7.9 years, complaining of monosymptomatic nocturnal enuresis. Baseline evaluations, at the first visit, included voiding diary, enuresis diary, uroflowmetry, urine osmolality, and urine and serum osmolality after a water deprivation test and electrocardiography. After the administration of medication, the changes in the enuretic episodes and adverse effects were evaluated every month. RESULTS: Sixteen children received medication, and after 2 weeks the drug response rate was 57.1% (4/7) in the imipramine group and 33.3% (3/9) in the DDAVP group. Ten of the 16 children completed the study. After 12 weeks of study, the response rate was 75% (3/4) in the imipramine group and 50% (3/6) in the DDAVP group. There were no significant differences in mean urine osmolalities and functional bladder capacities between the response and no-response groups. During the study, side effects developed in only three of the children in the imipramine group. Of these, one demonstrated tachycardia on a follow-up electrocardiography and another complained of irritability, insomnia, a dry mouth and blurred vision. Subsequently, the two children dropped out due to these side effects. CONCLUSIONS: The imipramine and DDAVP had similar therapeutic effects, but the DDAVP had fewer side effects, and was better tolerated, than the imipramine.
Asunto(s)
Niño , Humanos , Desamino Arginina Vasopresina , Electrocardiografía , Enuresis , Estudios de Seguimiento , Imipramina , Boca , Enuresis Nocturna , Concentración Osmolar , Estudios Prospectivos , Trastornos del Inicio y del Mantenimiento del Sueño , Taquicardia , Vejiga Urinaria , Privación de AguaRESUMEN
PURPOSE: To determine the reference values of hematologic and biochemical parameters of nutrition around the weaning period. METHODS: From February 1996 to March 1997, several nutritional laboratory values were evaluated in 130 healthy babies and 120 inpatients in the recovery stage of acute illness at six general hospitals. RESULTS: Reference values in 9-month-old healthy babies(range : 6-12 months) were hemoglobin 11.8+/-0.9g/dL, hematocrit 30.9+/-0.7%, serum ferritin 25.7+/-15.4ng/mL, total protein(TP) 6.5+/-0.5g/ dL, albumin 4.6+/-0.5g/dL, prealbumin 15.6+/-3.9mg/L, cholesterol 154.7+/-22.4mg/dL, calcium 10.1+/-0.5mg/dL, phosphorus 6.1+/-0.9mg/dL, alkaline phosphatase(ALP) 235.1+/-66.4U/L. Reference values in 15-month-old healthy babies(range : 13-18 months) were hemoglobin 12.3+/-1.0g/dL, hematocrit 30.9+/-0.4%, serum ferritin 20.4+/-11.2ng/mL, TP 6.8+/-0.6g/dL, albumin 4.7+/-0.5g/dL, prealbumin 18.1+/-4.6mg/L, cholesterol 163.1+/-24.2mg/dL, calcium 9.3+/-1.0mg/dL, phosphorus 6.0+/-0.8mg/dL and ALP 254.5+/-64.0U/L. Most reference values were significantly lower in inpatients than the healthy babies, except for serum ferritin level which was the opposite. There were no significant differences in reference values according to feeding and weaning practices. Incidence of anemia(hemoglobin200mg/dL) was 8.6% in 15-month-old healthy babies. CONCLUSION: This study presented the reference values of hemoglobin, hematocrit, serum ferritin, total protein, albumin, prealbumin, cholesterol, calcium, phosphorus and alkaline phosphatase around the weaining period. The current nutritional status of Korean babies around the weaning period was appropriate except for borderline iron deficiency.
Asunto(s)
Humanos , Lactante , Fosfatasa Alcalina , Calcio , Colesterol , Dieta , Ferritinas , Hematócrito , Hospitales Generales , Incidencia , Pacientes Internos , Hierro , Estado Nutricional , Fósforo , Prealbúmina , Valores de Referencia , DesteteRESUMEN
PURPOSE: To determine the reference values of hematologic and biochemical parameters of nutrition around the weaning period. METHODS: From February 1996 to March 1997, several nutritional laboratory values were evaluated in 130 healthy babies and 120 inpatients in the recovery stage of acute illness at six general hospitals. RESULTS: Reference values in 9-month-old healthy babies(range : 6-12 months) were hemoglobin 11.8+/-0.9g/dL, hematocrit 30.9+/-0.7%, serum ferritin 25.7+/-15.4ng/mL, total protein(TP) 6.5+/-0.5g/ dL, albumin 4.6+/-0.5g/dL, prealbumin 15.6+/-3.9mg/L, cholesterol 154.7+/-22.4mg/dL, calcium 10.1+/-0.5mg/dL, phosphorus 6.1+/-0.9mg/dL, alkaline phosphatase(ALP) 235.1+/-66.4U/L. Reference values in 15-month-old healthy babies(range : 13-18 months) were hemoglobin 12.3+/-1.0g/dL, hematocrit 30.9+/-0.4%, serum ferritin 20.4+/-11.2ng/mL, TP 6.8+/-0.6g/dL, albumin 4.7+/-0.5g/dL, prealbumin 18.1+/-4.6mg/L, cholesterol 163.1+/-24.2mg/dL, calcium 9.3+/-1.0mg/dL, phosphorus 6.0+/-0.8mg/dL and ALP 254.5+/-64.0U/L. Most reference values were significantly lower in inpatients than the healthy babies, except for serum ferritin level which was the opposite. There were no significant differences in reference values according to feeding and weaning practices. Incidence of anemia(hemoglobin200mg/dL) was 8.6% in 15-month-old healthy babies. CONCLUSION: This study presented the reference values of hemoglobin, hematocrit, serum ferritin, total protein, albumin, prealbumin, cholesterol, calcium, phosphorus and alkaline phosphatase around the weaining period. The current nutritional status of Korean babies around the weaning period was appropriate except for borderline iron deficiency.