The endothelial-mesenchymal transition in glioma and strategies for targeted therapy: research progress / 国际药学研究杂志

Endothelial-mesenchymal transition(EndoMT)is a pathophysiological progress that endothelial cells lose their specific phenotype,function and morphology and gradually transform to mesenchymal cells under the effect of certain stimulating factors. More and more researches have shown that EndoMT plays a key role in the occurrence and development as well as the invasion and metastasis of glioma. This paper reviews the EndoMT-related signaling pathways and their important effect on the angiogenesis,invasion,metastasis,immunosuppression and the drug resistance of glioma. Meanwhile, strategies for the EndoMT-targeted therapy are also summarized, so as to provide a reference for related studies and clinical treatment of glioma.