Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine

BACKGROUND: Advances in tissue engineering and regenerative medicine over the last three decades have made great progress in the development of diagnostic and therapeutic methodologies for damaged tissues. However, regenerative medicine is still not the first line of treatment for patients due to limited understanding of the tissue regeneration process. Therefore, it is prerequisite to develop molecular imaging strategies combined with appropriate contrast agents to validate the therapeutic progress of damaged tissues. METHODS: The goal of this review is to discuss the progress in the development of near-infrared (NIR) contrast agents and their biomedical applications for labeling cells and scaffolds, as well as monitoring the treatment progress of native tissue in living organisms. We also discuss the design consideration of NIR contrast agents for tissue engineering and regenerative medicine in terms of their physicochemical and optical properties. RESULTS: The use of NIR imaging system and targeted contrast agents can provide high-resolution and high sensitivity imaging to track/monitor the in vivo fate of administered cells, the degradation rate of implanted scaffolds, and the tissue growth and integration of surrounding cells during the therapeutic period. CONCLUSION: NIR fluorescence imaging techniques combined with targeted contrast agents can play a significant role in regenerative medicine by monitoring the therapeutic efficacy of implanted cells and scaffolds which would enhance the development of cell therapies and promote their successful clinical translations.

Real-Time Fluorescence Imaging in Thoracic Surgery / 대한흉부외과학회지

Near-infrared (NIR) fluorescence imaging provides a safe and cost-efficient method for immediate data acquisition and visualization of tissues, with technical advantages including minimal autofluorescence, reduced photon absorption, and low scattering in tissue. In this review, we introduce recent advances in NIR fluorescence imaging systems for thoracic surgery that improve the identification of vital tissues and facilitate the resection of tumorous tissues. When coupled with appropriate NIR fluorophores, NIR fluorescence imaging may transform current intraoperative thoracic surgery methods by enhancing the precision of surgical procedures and augmenting postoperative outcomes through improvements in diagnostic accuracy and reductions in the remission rate.

Real-Time Fluorescence Imaging in Thoracic Surgery

Near-infrared (NIR) fluorescence imaging provides a safe and cost-efficient method for immediate data acquisition and visualization of tissues, with technical advantages including minimal autofluorescence, reduced photon absorption, and low scattering in tissue. In this review, we introduce recent advances in NIR fluorescence imaging systems for thoracic surgery that improve the identification of vital tissues and facilitate the resection of tumorous tissues. When coupled with appropriate NIR fluorophores, NIR fluorescence imaging may transform current intraoperative thoracic surgery methods by enhancing the precision of surgical procedures and augmenting postoperative outcomes through improvements in diagnostic accuracy and reductions in the remission rate.

Evaluation of the Emergency Call / 대한마취과학회지

Sudden unexpected death, in terms of absolute loss of life, poses our greatest single medical problem today. As our knowledge of the mechanisms of cardiac arrest continues to increase, it is encouraging to note how it can be applied to clinical situations. A good example is the well-documented story of succinylcholine-induced hyperkalemia and the propensity of patients with severe trauma and burns to develop cardiac arrest. There seems to be little question that an effective hospital cardiopulmonary resuscitation committee can contribute significantly to a reduction in mortality from sudden death within the hospital. Relatively low rates of successful resuscitation in hospital art partially due to a lack of realization of therapeutic requirements for specific situations. Broad generalizations are helpful for educational purposes, but the field of cardiac resuscitation has become sufficiently sophisticated to require in-depth knowledge of modifications in resuscitation efforts as individually required. Therefore, the authors attempted to evaluate the 40 cases of emergency calls for the anesthesiologists during the period of August 1975 to July 1976. Evaluated results were as follows; l. Incidence of emergency calls to the anesthesiologist was 24.4%(164 death vs 40 calls). 2. The method of emergency call was not efficiently established among the teaching hospitals yet. 3. None of the cardiopulmonary resuscitation committees was established and operating among the teaching hospitals now. 4. A cardiopulmonary resuscitation committee should be responsible for providing a written plan of action, CPR training and practice sessions, and a record of CPR occurences available for periodic audit and review.