RESUMEN
Objective: to investigate the correlation of anti-mutated citrullinated vimentin [anti-MCV] titers with clinical manifestations and disease activity in a cohort of patients with established diagnosis of rheumatoid arthritis
Material and Methods: a total of 58 patients attending the rheumatology outpatient department of Fatima Memorial Hospital, Lahore were recruited in the study. Data of disease related parameters such as disease duration, medications, degree of pain [visual analog scale, VAS], disease activity score 28 [DAS 28], and health assessment questionnaire [HAQ] were recorded. Laboratory work up included erythrocyte sedimentation rate [ESR>20mm/hr considered positive], rheumatoid factor [determined by ELISA technique], anti-CCP antibody [ELISAlmmco Diagnostics, USA] and anti-MCVantibody [Cusabio Biotech Co. , Ltd, China]
Results: the anti-MCV antibody levels did correlate with the number of tender joints [p=0.001 ], swollen joints [p=0.001 ], VAS [p=0.330], ESR [p=0.001 ], DAS28 scores [p=0.001 ]. However, no significant correlation of anti MCV titers with HAQ scores [p=0.090] and anti-CCP titers [p=0.685] and serum RF titers [p=0 .621] was observed
Conclusion: in Significant correlation was noticed between the serum anti-MCV antibody titers and DAS-28 and other disease activity parameters besides HAQ-D and anti-CCP and RF titers