Buccoadhesive tablets for delivery of verapamil hci: design, in-vitro analysis and in-vivo evaluation

Buccoadhesive controlled release verapamil HCI tablets have been prepared using mucoadhesive polymers namely; sodium alginate [Na Alg], xanthan gum [XG] and gum tragacanth [GT] either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and in-vivo hypertension study. Tablets containing XG showed the highest swelling index and bio adhesive force. The maximum cumulative% released [100%] was observed in F7, F10 and FJl due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except Fl that it obeyes a diffusion model The buccoadhesive verapamil HCI tablet had suggested being promising for the transmucosal delivery of verapamil HCI and allowing a controlled drug delivery for 6 hrs

Formulation and evaluation of meloxicam gels for topical administration

For topical administration ofmeloxicam [ME], microemulsion gels and lipogels containing either ethyl oleate or oleic acid as an oil phase were prepared. In addition, Hydrogel and hydroalcoholic gels containing carbopol 940 as a gelling agent were also prepared. In-vitro drug release through cellophane membrane and permeation through the excised rabbit skin in Sorensen's phosphate buffer [pH 7.4] containing 1% w/v sodium lauryl sulphate were performed. The influence of initial drug concentration [0.5, 0.65, 1% w/w] was studied. The permeation properties of ME from ethyl oleate microemulsion which is the best formula achieved was studied in comparison to the commercially available piroxicam gel. Moreover, the anti-inflammatory activity of ME after oral and topical administration in rats was studied and compared to that of piroxicam gel. The results of an in-vitro drug release and its percutaneous permeation revealed that the ethyloleate microemulsion gel showed the highest results. Meloxicam gel [ethyl oleate microemulsion gel 1%] showed good protection against inflammation as compared to Feldene gel in rats